Print Email Facebook Twitter Adapting Temperature Predictions to MR Imaging in Treatment Position to Improve Simulation-Guided Hyperthermia for Cervical Cancer Title Adapting Temperature Predictions to MR Imaging in Treatment Position to Improve Simulation-Guided Hyperthermia for Cervical Cancer Author Vilasboas-Ribeiro, Iva (Erasmus MC) Sumser, Kemal (Eindhoven University of Technology) Nouwens, Sven (Eindhoven University of Technology) Feddersen, Theresa (Erasmus MC) Heemels, W. P.M.H. (Eindhoven University of Technology) van Rhoon, G.C. (TU Delft RST/Applied Radiation & Isotopes; Erasmus MC) Paulides, Margarethus M. (Eindhoven University of Technology) Date 2024 Abstract Hyperthermia treatment consists of elevating the temperature of the tumor to increase the effectiveness of radiotherapy and chemotherapy. Hyperthermia treatment planning (HTP) is an important tool to optimize treatment quality using pre-treatment temperature predictions. The accuracy of these predictions depends on modeling uncertainties such as tissue properties and positioning. In this study, we evaluated if HTP accuracy improves when the patient is imaged inside the applicator at the start of treatment. Because perfusion is a major uncertainty source, the importance of accurate treatment position and anatomy was evaluated using different perfusion values. Volunteers were scanned using MR imaging without ('planning setup') and with the MR-compatible hyperthermia device ('treatment setup'). Temperature-based quality indicators were used to assess the differences between the standard, apparent and the optimized hyperthermia dose. We conclude that pre-treatment imaging can improve HTP predictions accuracy but also, that tissue perfusion modelling is crucial if temperature-based optimization is applied. Subject Hyperthermia treatment planning (HTP)MR imagingoptimization approachperfusionthermal modeling To reference this document use: http://resolver.tudelft.nl/uuid:f649af0c-c451-4781-895b-e67c34016fbd DOI https://doi.org/10.1109/OJEMB.2023.3321990 Source IEEE Open Journal of Engineering in Medicine and Biology, 5, 99-106 Part of collection Institutional Repository Document type journal article Rights © 2024 Iva Vilasboas-Ribeiro, Kemal Sumser, Sven Nouwens, Theresa Feddersen, W. P.M.H. Heemels, G.C. van Rhoon, Margarethus M. Paulides Files PDF Adapting_Temperature_Pred ... Cancer.pdf 3.06 MB Close viewer /islandora/object/uuid:f649af0c-c451-4781-895b-e67c34016fbd/datastream/OBJ/view