Title
Vanadium-Containing Chloroperoxidase-Catalyzed Versatile Valorization of Phenols and Phenolic Acids
Author
Li, Huanhuan (Xi’an Jiaotong University)
Duan, Peigao (Xi’an Jiaotong University)
Huang, Yawen (Chinese Academy of Sciences)
Cui, Chengsen (Chinese Academy of Sciences)
Hollmann, F. (TU Delft BT/Biocatalysis) 
Ma, Yunjian (South China University of Technology)
Wang, Yonghua (South China University of Technology)
Zhang, Jie (Chinese Academy of Sciences)
Liu, Weidong (Chinese Academy of Sciences)
Zhang, Wuyuan (Chinese Academy of Sciences)
Date
2024
Abstract
The downstream product transformation of lignin depolymerization is of great interest in the production of high-value aromatic chemicals. However, this transformation is often impeded by chemical oxidation under harsh reaction conditions. In this study, we demonstrate that hypohalites generated in situ by the vanadium-containing chloroperoxidase from Curvularia inaequalis (CiVCPO) can halogenate various electron-rich and electron-poor phenol and phenolic acid substrates. Specifically, CiVCPO enabled decarboxylative halogenation, deformylative halogenation, halogenation, and direct oxidation reactions. The versatile transformation routes for the valorization of phenolic compounds showed up to 99% conversion and 99% selectivity, with a turnover number of 60,700 and a turnover frequency of 60 s-1 for CiVCPO. This study potentially expands the biocatalytic toolbox for lignin valorization.
Subject
biocatalysis
decarboxylation
halogenation
lignin valorization
vanadium-containing chloroperoxidase
To reference this document use:
http://resolver.tudelft.nl/uuid:f6a54572-b462-4df9-8a57-5a4645ad5b3c
DOI
https://doi.org/10.1021/acscatal.3c05333
Embargo date
2024-07-18
ISSN
2155-5435
Source
ACS Catalysis, 14 (3), 1733-1740
Bibliographical note
Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.
Part of collection
Institutional Repository
Document type
journal article
Rights
© 2024 Huanhuan Li, Peigao Duan, Yawen Huang, Chengsen Cui, F. Hollmann, Yunjian Ma, Yonghua Wang, Jie Zhang, Weidong Liu, Wuyuan Zhang