Print Email Facebook Twitter Revealing intraosseous blood flow in the human tibia with ultrasound Title Revealing intraosseous blood flow in the human tibia with ultrasound Author Salles, Sebastien (Sorbonne Université) Shepherd, Jami (Sorbonne Université; The University of Auckland) Vos, Hendrik J. (Erasmus MC) Renaud, G.G.J. (TU Delft ImPhys/Medical Imaging; Sorbonne Université) Date 2021 Abstract Intraosseous blood circulation is thought to have a critical role in bone growth and remodeling, fracture healing, and bone disorders. However, it is rarely considered in clinical practice because of the absence of a suitable noninvasive in vivo measurement technique. In this work, we assessed blood perfusion in tibial cortical bone simultaneously with blood flow in the superficial femoral artery with ultrasound imaging in five healthy volunteers. After suppression of stationary signal with singular-value-decomposition, pulsatile blood flow in cortical bone tissue is revealed, following the heart rate measured in the femoral artery. Using a method combining transverse oscillations and phase-based motion estimation, 2D vector flow was obtained in the cortex of the tibia. After spatial averaging over the cortex, the peak blood velocity along the long axis of the tibia was measured at four times larger than the peak blood velocity across the bone cortex. This suggests that blood flow in central (Haversian) canals is larger than in perforating (Volkmann's) canals, as expected from the intracortical vascular organization in humans. The peak blood velocity indicates a flow from the endosteum to the periosteum and from the heart to the foot for all subjects. Because aging and the development of bone disorders are thought to modify the direction and velocity of intracortical blood flow, their quantification is crucial. This work reports for the first time an in vivo quantification of the direction and velocity of blood flow in human cortical bone. Subject AgingAnalysis/quantitation of boneBone ultrasoundMusculoskeletal diseasesRadiologyOA-Fund TU Delft To reference this document use: http://resolver.tudelft.nl/uuid:1a973474-9a0e-4c3d-adb6-a23080f196b8 DOI https://doi.org/10.1002/jbm4.10543 ISSN 2473-4039 Source JBMR Plus, 5 (11) Part of collection Institutional Repository Document type journal article Rights © 2021 Sebastien Salles, Jami Shepherd, Hendrik J. Vos, G.G.J. Renaud Files PDF jbm4.10543.pdf 2.65 MB Close viewer /islandora/object/uuid:1a973474-9a0e-4c3d-adb6-a23080f196b8/datastream/OBJ/view