Print Email Facebook Twitter Local Activation Time Estimation in Fractionated Electrograms of Cardiac Mappings Title Local Activation Time Estimation in Fractionated Electrograms of Cardiac Mappings Author Abdi, Bahareh (TU Delft Signal Processing Systems) van der Veen, A.J. (TU Delft Signal Processing Systems) de Groot, N.M.S. (Erasmus MC) Hendriks, R.C. (TU Delft Signal Processing Systems) Date 2019 Abstract In this study, we propose a novel approach for estimation of local activation times (LATs) in fractionated electrograms. Using an electrophysiological tissue model, we first formulate the electrogram array as a convolution of transmembrane currents with a distance kernel. These currents are more local activities and less affected by the heterogeneity in the tissue compared to electrograms. We then deconvolve the distance kernel with the electrograms to reconstruct the transmembrane current. To stabilize the solution of this ill-posed deconvolution, we use spatio-temporal total variation as a regularization. This helps to preserve sharp spatial and temporal deflections in the currents that are of higher importance in LAT estimation. Finally, the maximum negative slope of the reconstructed transmembrane currents are used to estimate the LATs. Instrumental comparison to two reference approaches shows that the proposed approach performs better in estimating the LATs in fractionated electrograms. To reference this document use: http://resolver.tudelft.nl/uuid:213900a8-ddd8-4f0e-8cfe-953b4e87d283 DOI https://doi.org/10.1109/EMBC.2019.8856683 Publisher IEEE, Danvers ISBN 978-1-5386-1312-2 Source 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2019 Event EMBC 2019, 2019-07-23 → 2019-07-27, Berlin, Germany Series Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, 1557-170X Bibliographical note Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public Part of collection Institutional Repository Document type conference paper Rights © 2019 Bahareh Abdi, A.J. van der Veen, N.M.S. de Groot, R.C. Hendriks Files PDF 08856683.pdf 917.72 KB Close viewer /islandora/object/uuid:213900a8-ddd8-4f0e-8cfe-953b4e87d283/datastream/OBJ/view