Biomechanical evaluation of additively manufactured patient-specific mandibular cage implants designed with a semi-automated workflow

Biomechanical evaluation of additively manufactured patient-specific mandibular cage implants designed with a semi-automated workflow: A cadaveric and retrospective case study

van Kootwijk, A. (Erasmus MC)
Jonker, B. P. (Erasmus MC)
Wolvius, E. B. (Erasmus MC)
Cruz Saldivar, M. (TU Delft Biomaterials & Tissue Biomechanics)
Leeflang, M.A. (TU Delft Biomaterials & Tissue Biomechanics)
Zhou, J. (TU Delft Biomaterials & Tissue Biomechanics)
Tümer, N. (TU Delft Biomaterials & Tissue Biomechanics)
Mirzaali, Mohammad J. (TU Delft Biomaterials & Tissue Biomechanics)
Zadpoor, A.A. (TU Delft Biomaterials & Tissue Biomechanics)

2023

Objective: Mandibular reconstruction using patient-specific cage implants is a promising alternative to the vascularized free flap reconstruction for nonirradiated patients with adequate soft tissues, or for patients whose clinical condition is not conducive to microsurgical reconstruction. This study aimed to assess the biomechanical performance of 3D printed patient-specific cage implants designed with a semi-automated workflow in a combined cadaveric and retrospective case series study. Methods: We designed cage implants for two human cadaveric mandibles using our previously developed design workflow. The biomechanical performance of the implants was assessed with the finite element analysis (FEA) and quasi-static biomechanical testing. Digital image correlation (DIC) was used to measure the full-field strains and validate the FE models by comparing the distribution of maximum principal strains within the bone. The retrospective study of a case series involved three patients, each of whom was treated with a cage implant of similar design. The biomechanical performance of these implants was evaluated using the experimentally validated FEA under the scenarios of both mandibular union and nonunion. Results: No implant or screw failure was observed prior to contralateral bone fracture during the quasi-static testing of both cadaveric mandibles. The FEA and DIC strain contour plots indicated a strong linear correlation (r = 0.92) and a low standard error (SE=29.32με), with computational models yielding higher strain values by a factor of 2.7. The overall stresses acting on the case series’ implants stayed well below the yield strength of additively manufactured (AM) commercially pure titanium, when simulated under highly strenuous chewing conditions. Simulating a full union between the graft and remnant mandible yielded a substantial reduction (72.7±1.5%) in local peak stresses within the implants as compared to a non-bonded graft. Conclusions: This study shows the suitability of the developed semi-automated workflow in designing patient-specific cage implants with satisfactory mechanical functioning under demanding chewing conditions. The proposed workflow can aid clinical engineers in creating reconstruction systems and streamlining pre-surgical planning. Nevertheless, more research is still needed to evaluate the osteogenic potential of bone graft insertions.

3D printing
Automated implant design
Biomechanical study
Finite element method
Mandibular reconstruction
Patient-specific implant

http://resolver.tudelft.nl/uuid:5bff66fb-4568-4659-b0e2-a7181dbf7ef6

https://doi.org/10.1016/j.jmbbm.2023.106097

1751-6161

Journal of the Mechanical Behavior of Biomedical Materials, 146

Institutional Repository

journal article

© 2023 A. van Kootwijk, B. P. Jonker, E. B. Wolvius, M. Cruz Saldivar, M.A. Leeflang, J. Zhou, N. Tümer, Mohammad J. Mirzaali, A.A. Zadpoor