Impact of Thermodynamic Principles in Systems Biology

Journal article (2010)

Authors

Department
Biotechnology (AS) (TU Delft)
Copyright: © 2010 Heijnen, J.J.; Springer
DOI: https://doi.org/doi:10.1007/10_2009_63
Model reduction Thermodynamics Gene regulation Systems biology Stoichiometry Black box kinetics Lin-log kinetics Metabolic networks Pseudo-steady state
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Published Date

12-02-2010

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Source:

Advances in Biochemical Engineering Biotechnology, Febr 12, 2010

ISSN:

0724-6145

Faculty

Applied Sciences

Department

Biotechnology

Abstract

It is shown that properties of biological systems which are relevant for systems biology motivated mathematical modelling are strongly shaped by general thermodynamic principles such as osmotic limit, Gibbs energy dissipation, near equilibria and thermodynamic driving force. Each of these aspects will be demonstrated both theoretically and experimentally.

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