Print Email Facebook Twitter Valorization of Small Alkanes by Biocatalytic Oxyfunctionalization Title Valorization of Small Alkanes by Biocatalytic Oxyfunctionalization Author Mahor, Durga (Chinese Academy of Sciences; Indian Institute of Science Education and Research, Berhampur) Cong, Zhiqi (Chinese Academy of Sciences) Weissenborn, Martin J. (Leibniz Institut of Plant Biochemistry, Halle) Hollmann, F. (TU Delft BT/Biocatalysis) Zhang, Wuyuan (Chinese Academy of Sciences) Date 2021 Abstract The oxidation of alkanes into valuable chemical products is a vital reaction in organic synthesis. This reaction, however, is challenging, owing to the inertness of C−H bonds. Transition metal catalysts for C−H functionalization are frequently explored. Despite chemical alternatives, nature has also evolved powerful oxidative enzymes (e. g., methane monooxygenases, cytochrome P450 oxygenases, peroxygenases) that are capable of transforming C−H bonds under very mild conditions, with only the use of molecular oxygen or hydrogen peroxide as electron acceptors. Although progress in alkane oxidation has been reviewed extensively, little attention has been paid to small alkane oxidation. The latter holds great potential for the manufacture of chemicals. This Minireview provides a concise overview of the most relevant enzyme classes capable of small alkanes (C<6) oxyfunctionalization, describes the essentials of the catalytic mechanisms, and critically outlines the current state-of-the-art in preparative applications. Subject alkanesbiocatalysisenzymesoxidationoxyfunctionalization To reference this document use: http://resolver.tudelft.nl/uuid:eff7f12f-b0bb-4d27-adcf-0449402093f7 DOI https://doi.org/10.1002/cssc.202101116 Embargo date 2022-01-20 ISSN 1864-5631 Source ChemSusChem (Print): chemistry & sustainability, energy & materials, 15 (9), 1-12 Bibliographical note Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public. Part of collection Institutional Repository Document type review Rights © 2021 Durga Mahor, Zhiqi Cong, Martin J. Weissenborn, F. Hollmann, Wuyuan Zhang Files PDF ChemSusChem_2021_Mahor_Va ... zation.pdf 2.82 MB Close viewer /islandora/object/uuid:eff7f12f-b0bb-4d27-adcf-0449402093f7/datastream/OBJ/view