SPECT/CT Imaging of Pluronic Nanocarriers with Varying Poly(ethylene oxide) Block Length and Aggregation State

Journal article (2016)

Authors

Alexandra Arranja External organisation
O. Ivashchenko MILabs B.V., RST/Biomedical Imaging - AS , University Medical Center Utrecht
A.G. Denkova RST/Applied Radiation & Isotopes - AS
Antonia Denkova RST/Applied Radiation & Isotopes - AS
Antonia G. Denkova RST/Applied Radiation & Isotopes - AS
K.M. Morawska Universiteit Gent
Sandra Van Vlierberghe Universiteit Gent
Peter Dubruel Universiteit Gent
Gilles Waton Institut Charles Sadron
F.J. Beekman MILabs B.V., RST/Biomedical Imaging - AS , University Medical Center Utrecht
Freek J. Beekman MILabs B.V., RST/Biomedical Imaging - AS , University Medical Center Utrecht
François Schosseler Institut Charles Sadron
Eduardo Mendes ChemE/Advanced Soft Matter - AS
E. Mendes ChemE/Advanced Soft Matter - AS
Research Group
RST/Biomedical Imaging (AS) (TU Delft)
Copyright: © 2016 Alexandra Arranja, O. Ivashchenko, A.G. Denkova, K.M. Morawska, Sandra Van Vlierberghe, Peter Dubruel, Gilles Waton, F.J. Beekman, François Schosseler, E. Mendes
DOI: https://doi.org/10.1021/acs.molpharmaceut.5b00958
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Published Date

07-03-2016

Language

English

Reuse Rights

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Faculty

Applied Sciences

Department

RST/Radiation, Science and Technology

Research Group

RST/Biomedical Imaging

Abstract

Optimal biodistribution and prolonged circulation of nanocarriers improve diagnostic and therapeutic effects of enhanced permeability and retention-based nanomedicines. Despite extensive use of Pluronics in polymer-based pharmaceuticals, the influence of different poly(ethylene oxide) (PEO) block length and aggregation state on the biodistribution of the carriers is rather unexplored. In this work, we studied these effects by evaluating the biodistribution of Pluronic unimers and cross-linked micelles with different PEO block size. In vivo biodistribution of 111In-radiolabeled Pluronic nanocarriers was investigated in healthy mice using single photon emission computed tomography. All carriers show fast uptake in the organs from the reticuloendothelial system followed by a steady elimination through the hepatobiliary tract and renal filtration. The PEO block length affects the initial renal clearance of the compounds and the overall liver uptake. The aggregation state influences the long-term accumulation of the nanocarriers in the liver. We showed that the circulation time and elimination pathways can be tuned by varying the physicochemical properties of Pluronic copolymers. Our results can be beneficial for the design of future Pluronic-based nanomedicines.

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