Print Email Facebook Twitter Automated control for investigation of the insufflation-ventilation interaction in experimental laparoscopy Title Automated control for investigation of the insufflation-ventilation interaction in experimental laparoscopy Author van Weteringen, Willem (Erasmus MC) Sterke, F. (TU Delft Medical Instruments & Bio-Inspired Technology; Erasmus MC) Vlot, J. (Erasmus MC) Wijnen, René M.H. (Erasmus MC) Dankelman, J. (TU Delft Medical Instruments & Bio-Inspired Technology) Date 2023 Abstract In laparoscopic surgery the abdominal cavity is insufflated with pressurized carbon dioxide gas to create workspace. This pressure is exerted through the diaphragm onto the lungs, competing with ventilation and hampering it. In clinical practice the difficulty of optimizing this balance can lead to the application of harmfully high pressures. This study set out to create a research platform for the investigation of the complex interaction between insufflation and ventilation in an animal model. The research platform was constructed to incorporate insufflation, ventilation and relevant hemodynamic monitoring devices, controlling insufflation and ventilation from a central computer. The core of the applied methodology is the fixation of physiological parameters by applying closed-loop control of specific ventilation parameters. For accurate volumetric measurements the research platform can be used in a CT scanner. An algorithm was designed to keep blood carbon dioxide and oxygen values stable, minimizing the effect of fluctuations on vascular tone and hemodynamics. This design allowed stepwise adjustment of insufflation pressure to measure the effects on ventilation and circulation. A pilot experiment in a porcine model demonstrated adequate platform performance. The developed research platform and protocol automation have the potential to increase translatability and repeatability of animal experiments on the biomechanical interactions between insufflation and ventilation. To reference this document use: http://resolver.tudelft.nl/uuid:ff938f5d-ceee-4113-ba42-cabb34d80247 DOI https://doi.org/10.1371/journal.pone.0285108 ISSN 1932-6203 Source PLoS ONE, 18 (5) Part of collection Institutional Repository Document type journal article Rights © 2023 Willem van Weteringen, F. Sterke, J. Vlot, René M.H. Wijnen, J. Dankelman Files PDF journal.pone.0285108.pdf 1.96 MB Close viewer /islandora/object/uuid:ff938f5d-ceee-4113-ba42-cabb34d80247/datastream/OBJ/view