On the identification of hypoxic regions in subject-specific cerebral vasculature by combined CFD/MRI

A long-time exposure to lack of oxygen (hypoxia) in some regions of the cerebrovascular system is believed to be one of the causes of cerebral neurological diseases. In the present study, we show how a combination of magnetic resonance imaging (MRI) and computational fluid dynamics (CFD) can provide a noninvasive alternative for studying...

Geometrically induced wall shear stress variability in CFD-MRI coupled simulations of blood flow in the thoracic aortas

Aortic aneurysm is associated with aberrant blood flow and wall shear stress (WSS). This can be studied by coupling magnetic resonance imaging (MRI) with computational fluid dynamics (CFD). For patient-specific simulations, extra attention should be given to the variation in segmentation of the MRI data-set and its effect on WSS. We performed...

A calibrated physical flow standard for medical perfusion imaging

In the medical sector, various imaging methodologies or modalities (e.g. MRI, PET, CT) are used to assess the health of various parts of the bodies of patients. One such investigation is the blood flow or perfusion of the heart muscle, expressed as the (blood) flow rate normalized by the mass of the volume of interest. Currently there is no...

PC-MRI Blood-Flow measurements: Visualization and Data Assimilation

Heart and vessel diseases, or cardiovascular diseases (CVDs), are globally the main cause of mortality and morbidity. The blood flow plays an important role in their occurrence and progression. Therefore, knowledge of the blood flow is of key importance to reduce and threat these diseases. This knowledge requires both high-quality data and an...