A multi-axis robot-based bioprinting system supporting natural cell function preservation and cardiac tissue fabrication

Despite the recent advances in artificial tissue and organ engineering, how to generate large size viable and functional complex organs still remains as a grand challenge for regenerative medicine. Three-dimensional bioprinting has demonstrated its advantages as one of the major methods in fabricating simple tissues, yet it still faces...

An omics-based framework for assessing the health risk of antimicrobial resistance genes

Antibiotic resistance genes (ARGs) are widespread among bacteria. However, not all ARGs pose serious threats to public health, highlighting the importance of identifying those that are high-risk. Here, we developed an ‘omics-based’ framework to evaluate ARG risk considering human-associated-enrichment, gene mobility, and host pathogenicity....

Tidal-flat reclamation aggravates potential risk from storm impacts

A better understanding of how tidal-flat reclamation changes the flood hazard is critical for climate-proofing coastal flood defense design of heavily urbanized areas. Since the 1950s, large-scale reclamation has been performed along the Shanghai coast, China, to fulfill the land demands of city expansion. We now show that the loss of tidal...