Transport receptor occupancy in nuclear pore complex mimics

Nuclear pore complexes (NPCs) regulate all molecular transport between the nucleus and the cytoplasm in eukaryotic cells. Intrinsically disordered Phe-Gly nucleoporins (FG-Nups) line the central conduit of NPCs to impart a selective barrier where large proteins are excluded unless bound to a transport receptor (karyopherin; Kap). Here, we...

Feasibility of mooring system optimization for floating wind turbines in deep water based on static analysis

The goal of this thesis is to investigate the feasibility of optimizing the mooring line characteristics of a semi-taut (chain – polyester – chain) mooring system in combination with drag embedded anchors for a 12 MW wind turbine supported by a semi-submersible in deep water, based on static analysis of the Ultimate Limit State (ULS) condition....

A designer FG-Nup that reconstitutes the selective transport barrier of the nuclear pore complex

Nuclear Pore Complexes (NPCs) regulate bidirectional transport between the nucleus and the cytoplasm. Intrinsically disordered FG-Nups line the NPC lumen and form a selective barrier, where transport of most proteins is inhibited whereas specific transporter proteins freely pass. The mechanism underlying selective transport through the NPC is...

Spatial structure of disordered proteins dictates conductance and selectivity in nuclear pore complex mimics

Nuclear pore complexes (NPCs) lined with intrinsically disordered FG-domains act as selective gatekeepers for molecular transport between the nucleus and the cytoplasm in eukaryotic cells. The underlying physical mechanism of the intriguing selectivity is still under debate. Here, we probe the transport of ions and transport receptors through...

Las Brisas de Amador, the feasibility and preliminary design of a cruise terminal

Molecular dynamics study of dislocation nucleation from a crack tip

Subcontracting engineering for a multinational shipbuider

Studie naar vergelijkingswerven

Fracture of disordered three-dimensional spring networks: A computer simulation methodology