Shack-Hartmann sensor based optical quality testing of whole slide imaging systems for digital pathology

Whole Slide Imaging (WSI) systems are used in the emerging field of digital pathology for capturing high-resolution images of tissue slides at high throughput. We present a technique to measure the optical aberrations of WSI systems using a Shack-Hartmann wavefront sensor as a function of field position. The resulting full-field aberration maps...

Control for sensorless optical wavefront correction

The acquisition of high resolution images is essential for the early detection of eye diseases. To acquire such high resolution images, it is necessary to correct for monochromatic aberrations introduced by the imaging system and the eye itself. Currently, adaptive optics systems are used to correct these aberrations and thereby achieve a higher...

Modeling of Image Formation in Cryo-Electron Microscopy

Knowledge of the structure of biological specimens is crucial for understanding life. Cryo-electron microscopy (cryo-EM) permits structural studies of biological specimen at their near-native state. The research performed in this thesis represents one of two subprojects of the FOM industrial partnership program with FEI Company. The common aim...