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Remmerswaal, Evan (author)
Objective: This work focuses on the feasibility of using Electrical Impedance Spectroscopy (EIS) to differentiate between cancerous and healthy tissues in real-time alongside the GI tract. This is to see whether it is possible to support surgeons when taking biopsies, or to see if it is possible to make biopsies obsolete with EIS. Methods: The...
master thesis 2023
document
Mourragui, S.M.C. (author)
Extensive efforts in cancer research over the past decades have markedly improved diagnosis and treatments, leading to better outcomes for cancer patients. Paradoxically, however, these discoveries have begun to shed light on a level of complexity that rules out the emergence of a universal cancer treatment. As any tumor is now known to be...
doctoral thesis 2023
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Becqué, Yvonne N. (author), van der Wel, Maaike (author), Aktan-Arslan, Muzeyyen (author), Driel, Anne Geert van (author), Rietjens, J.A.C. (author), van der Heide, Agnes (author), Witkamp, Erica (author)
Objective: Family caregivers are often intensively involved in palliative and end-of-life cancer care. A variety of interventions to support family caregivers have been developed, differing in target population, modality, and components. We aimed to systematically examine characteristics and the effectiveness of interventions to support...
review 2023
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Tepeli, Y.I. (author), Seale, C.F. (author), P. Gonçalves, Joana (author)
Motivation<br/><br/>Anti-cancer therapies based on synthetic lethality (SL) exploit tumour vulnerabilities for treatment with reduced side effects, by targeting a gene that is jointly essential with another whose function is lost. Computational prediction is key to expedite SL screening, yet existing methods are vulnerable to prevalent selection...
journal article 2023
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Fokkinga, E.P. (author), Hernandez-Tamames, J.A. (author), Ianus, Andrada (author), Nilsson, Markus (author), Tax, Chantal M.W. (author), Perez-Lopez, Raquel (author), Grussu, Francesco (author)
Diffusion-weighted magnetic resonance imaging (DW-MRI) aims to disentangle multiple biological signal sources in each imaging voxel, enabling the computation of innovative maps of tissue microstructure. DW-MRI model development has been dominated by brain applications. More recently, advanced methods with high fidelity to histology are...
review 2023
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Westendorp, Janine (author), Geerse, Olaf P. (author), van der Lee, Marije L. (author), Schoones, Jan W. (author), van Vliet, Milon H.M. (author), Wit, Tamara (author), Evers, A.W.M. (author), van Vliet, Liesbeth M. (author)
Objective: Issues regarding clinician communication remain an important source of complaints within healthcare. This systematic review aims to determine cancer patients' and their family caregivers' views on which clinicians' communication behaviors can harm (i.e. eliciting negative feelings/consequences for patients/family caregivers)....
review 2023
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Karaosmanoğlu, Eda (author)
In Turkey, roughly 3000 children and adolescents are diagnosed with cancer every year (Kebudi, 2012). Although there are different types of pediatric cancers, their trajectory is similar and filled with various physical and psychosocial challenges for the patients and their families. Moreover, cancer usually causes a drastic life change for the...
master thesis 2022
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Androulakis, Ioannis (author), Sumser, Kemal (author), Machielse, Melanie N.D. (author), Koppert, Linetta (author), Jager, Agnes (author), Nout, Remi (author), Franckena, Martine (author), van Rhoon, G.C. (author), Curto, Sergio (author)
Objective: The addition of hyperthermia in the treatment of intact breast cancer with the aim to improve local response is currently in a research phase. First, optimal hyperthermia devices need to be developed, for which a diverse, anatomically and pathologically accurate set of patient models is necessary. Methods: To investigate the...
journal article 2022
document
Seale, C.F. (author), Tepeli, Y.I. (author), P. Gonçalves, Joana (author)
Motivation<br/>Synthetic lethality (SL) between two genes occurs when simultaneous loss of function leads to cell death. This holds great promise for developing anti-cancer therapeutics that target synthetic lethal pairs of endogenously disrupted genes. Identifying novel SL relationships through exhaustive experimental screens is challenging,...
journal article 2022
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Akolawala, Q. (author), Rovituso, M. (author), Versteeg, Henri H. (author), Rondon, Araci M.R. (author), Accardo, A. (author)
Glioblastoma (GBM) is a devastating cancer of the brain with an extremely poor prognosis. For this reason, besides clinical and preclinical studies, novel in vitro models for the assessment of cancer response to drugs and radiation are being developed. In such context, three-dimensional (3D)-engineered cellular microenvironments, compared to...
journal article 2022
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van Groeningen, Boris (author)
Using RNA sequence data for predicting patient properties is fairly common by now. In this paper, Variational Auto-Encoders (VAEs) are used to assist in this process. VAEs are a type of neural network seeking to encode data into a smaller dimension called latent space. These latent features are then used to do downstream task analysis such as...
bachelor thesis 2021
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Jochems, Fleur (author), Thijssen, Bram (author), De Conti, Giulia (author), Jansen, Robin (author), Pogacar, Ziva (author), Groot, Kelvin (author), Wang, Liqin (author), Schepers, Arnout (author), Wessels, L.F.A. (author)
Cellular senescence is characterized as a stable proliferation arrest that can be triggered by multiple stresses. Most knowledge about senescent cells is obtained from studies in primary cells. However, senescence features may be different in cancer cells, since the pathways that are involved in senescence induction are often deregulated in...
journal article 2021
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Luu, Chiwei (author)
The aim of this project was to stimulate young children with cancer to engage in physical play to decrease the stagnation of their physical development. Children from the age of 2 to 5 are in the middle of their physical growth and development. This is also the age group with the highest risk of being diagnosed with acute lymphoblastic leukaemia...
master thesis 2018
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De Ruiter, J. R. (author), Wessels, L.F.A. (author), Jonkers, J. (author)
Cancer is a complex disease in which cells progressively accumulate mutations disrupting their cellular processes. A fraction of these mutations drive tumourigenesis by affecting oncogenes or tumour suppressor genes, but many mutations are passengers with no clear contribution to tumour development. The advancement of DNA and RNA sequencing...
review 2018
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Tolios, I. (author)
Lung tumors are heterogeneous entities consisting of distinct intra-tumor regions with different biological characteristics. Currently, the only means to explore and analyze these distinct intra-tumor regions is to inspect several image acquisitions. From these, per-voxel functional tissue parameters, representative of tissue properties, are...
master thesis 2016
document
Babaei, S. (author)
Cancer is a complex disease that results from alterations in genes that control the growth and division mechanisms of the cell. Identifying cancer-associated genes and pathways through which these genes influence cellular function is the key challenge in cancer re- search. This thesis proposes novel computational approaches that integrate data...
doctoral thesis 2015
document
Verlaan, P.J. (author)
The incidence of cancer is increasing each year: more people are getting in contact with cancer (they get cancer themselves or close relatives get cancer). In order to keep up with this growing group of patients, the Antoni van Leeuwenhoek hospital (NKI/AVL) is currently undergoing a renovation. Patient satisfaction is put as a primary...
master thesis 2015
document
Dsouza, A. (author)
Pool is an activity kit that helps family members to connect with each other and builds family strength, by making them more aware and appreciative of each other. It builds on the idea that more aware and appreciative family members can lead to a greater perception of family strength. This family strength leads to a greater sense of self...
master thesis 2015
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Wang, L. (author)
master thesis 2015
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Rosas Escobar, J.M. (author)
Organs on chips are a novel set of devices whose aim is to mimic cellular in-vivo conditions of the human physiology within a microchip. The need of reliable disease models, particularly for the development of pharmaceutical drugs, has drawn increased attention as the current widespread models; static cell cultures and animal tests, have proven...
master thesis 2014
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