Spatial relationships in the urothelial and head and neck tumor microenvironment predict response to combination immune checkpoint inhibitors

Immune checkpoint inhibitors (ICI) can achieve remarkable responses in urothelial cancer (UC), which may depend on tumor microenvironment (TME) characteristics. However, the relationship between the TME, usually characterized by immune cell density, and response to ICI is unclear. Here, we quantify the TME immune cell densities and spatial...

Frustumbug: a 3D mapless stereo-vision-based bug algorithm for Micro Air Vehicles

Obstacle avoidance is an important capability for flying robots. But for robots with limited resources, such as small drones this becomes particularly challenging. Bug algorithms have been proposed to solve path planning with only minimal resources. And stereo vision provides a rich description of the world for limited weight but typically has a...

Nitrous oxide emission from full-scale municipal aerobic granular sludge

The nitrous oxides emission was measured over 7 months in the full-scale aerobic granular sludge plant in Dinxperlo, the Netherlands. Nitrous oxide concentrations were measured in the bulk liquid and the off-gas of the Nereda® reactor. Combined with the batch wise operation of the reactor, this gave a high information density and a better...

Solving the Multi-Agent Path Finding with Waypoints Problem Using Subdimensional Expansion

Little to no research has been done on the multi-agent path finding with waypoints problem (MAPFW) even though it has many important real world applications. In this paper we extend an existing algorithm for the multi-agent path finding problem (MAPF) called M* \cite{New}. We do so by ordering the waypoints using a Travelling salesman problem...

Cryo-CMOS interfaces for large-scale quantum computers

Cryogenic CMOS (cryo-CMOS) is a viable technology for the control interface of the large-scale quantum computers able to address non-trivial problems. In this paper, we demonstrate state-of-the-art cryo-CMOS circuits and systems for such application and we discuss the challenges still to be faced on the path towards practical quantum...

Short-range magnetic correlations and spin dynamics in the paramagnetic regime of (Mn,Fe)2(P,Si)

The spatial and temporal correlations of magnetic moments in the paramagnetic regime of (Mn,Fe)2(P,Si) have been investigated by means of polarized neutron diffraction and muon-spin relaxation techniques. Short-range magnetic correlations are present at temperatures far above the ferromagnetic transition temperature (TC). This leads to...

Activeren in colleges – mogelijkheden en effecten onderzocht

een goed rapport voor de Nederlandse waterleidingingenieur?