Rapid Prototyping of Organ-on-a-Chip Devices Using Maskless Photolithography

Organ-on-a-chip (OoC) and microfluidic devices are conventionally produced using microfabrication procedures that require cleanrooms, silicon wafers, and photomasks. The prototyping stage often requires multiple iterations of design steps. A simplified prototyping process could therefore offer major advantages. Here, we describe a rapid and...

Enabling actuation and sensing in organs-on-chip using electroactive polymers

Organ-on-chip (OoC) devices are in rising demand for high-throughput and low-cost development and toxico-logical screening of chemicals and pharmaceuticals, as they accurately mimic in vitro physiological conditions as in the human body. In particular, OoCs are urgently needed for screening cardiovascular drug toxicity. Physiological relevance...

Enabling actuation and sensing in organs-on-chip using electroactive polymers

•Actuation has been succesfully performed for 2h30 with no side effects nor<br/>delimination of the human tissue <br/>•0.1 % strain has been achieved during the actutaion mode, close to the<br/>strain experienced in vivo by vSMCs <br/>•0.72 V/mm sensitivity has been shown on the sensing mode <br/>•Batch fabrication and downscaling will be...