Impact of partial coherence on the apparent optical transfer function derived from the response to amplitude edges

We present an investigation of the impact of partial coherence on optical imaging systems with the focus on whole slide imaging (WSI) systems for digital pathology. The investigation is based on the analysis of the edge response of the optical system, which gives rise to an apparent optical transfer function (OTF) that can be linked to two...

Whole slide imaging systems for digital pathology

Digital pathology is based on the use of digital images of tissues for diagnosis of diseases. In the emerging clinical practice of digital pathology, images of tissue slides are acquired with a high-resolution and high-throughput automated microscope, a so called Whole Slide Imaging (WSI) system. We designed, built and characterized a modular...

UWB pulse detection and TOA estimation using GLRT

In this paper, a novel statistical approach is presented for time-of-arrival (TOA) estimation based on first path (FP) pulse detection using a sub-Nyquist sampling ultra-wide band (UWB) receiver. The TOA measurement accuracy, which cannot be improved by averaging of the received signal, can be enhanced by the statistical processing of a...

Shack-Hartmann sensor based optical quality testing of whole slide imaging systems for digital pathology

Whole Slide Imaging (WSI) systems are used in the emerging field of digital pathology for capturing high-resolution images of tissue slides at high throughput. We present a technique to measure the optical aberrations of WSI systems using a Shack-Hartmann wavefront sensor as a function of field position. The resulting full-field aberration maps...