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Miedema, Rene (author), Strydis, C. (author)IntroductionIn-silico simulations are a powerful tool in modern neuroscience for enhancing our understanding of complex brain systems at various physiological levels. To model biologically realistic and detailed systems, an ideal simulation platform must possess: (1) high performance and performance scalability, (2) flexibility, and (3) ease of...journal article 2024
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De Ridder, Dirk (author), Siddiqi, M.A. (author), Dauwels, J.H.G. (author), Serdijn, W.A. (author), Strydis, C. (author)Objectives: Current techniques in brain stimulation are still largely based on a phrenologic approach that a single brain target can treat a brain disorder. Nevertheless, meta-analyses of brain implants indicate an overall success rate of 50% improvement in 50% of patients, irrespective of the brain-related disorder. Thus, there is still a...review 2024
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Brown, Michael D. (author), Generowicz, Bastian S. (author), Dijkhuizen, Stephanie (author), Koekkoek, Sebastiaan K.E. (author), Strydis, C. (author), Bosch, Johannes G. (author), Arvanitis, Petros (author), Springeling, Geert (author), Leus, G.J.T. (author), De Zeeuw, Chris I. (author), Kruizinga, P. (author)Four-dimensional ultrasound imaging of complex biological systems such as the brain is technically challenging because of the spatiotemporal sampling requirements. We present computational ultrasound imaging (cUSi), an imaging method that uses complex ultrasound fields that can be generated with simple hardware and a physical wave prediction...journal article 2024
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Siddiqi, M.A. (author), Hernández, Jan Andrés Galvan (author), Gebregiorgis, A.B. (author), Bishnoi, R.K. (author), Strydis, C. (author), Hamdioui, S. (author), Taouil, M. (author)Next-generation personalized healthcare devices are undergoing extreme miniaturization in order to improve user acceptability. However, such developments make it difficult to incorporate cryptographic primitives using available target tech-nologies since these algorithms are notorious for their energy consumption. Besides, strengthening these...conference paper 2023
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Betting, J. L. F. (author), Zeeuw, C. I. De (author), Strydis, C. (author)The cloud has become a powerful and useful environment for the deployment of High-Performance Computing (HPC) applications, but the large number of available instance types poses a challenge in selecting the optimal platform. Users often do not have the time or knowledge necessary to make an optimal choice. Recommender systems have been...conference paper 2023
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Diware, S.S. (author), Dash, Sudeshna (author), Gebregiorgis, A.B. (author), Joshi, Rajiv V. (author), Strydis, C. (author), Hamdioui, S. (author), Bishnoi, R.K. (author)Timely detection of cardiac arrhythmia characterized by abnormal heartbeats can help in the early diagnosis and treatment of cardiovascular diseases. Wearable healthcare devices typically use neural networks to provide the most convenient way of continuously monitoring heart activity for arrhythmia detection. However, it is challenging to...journal article 2023
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Panagiotou, S. (author), Sidiropoulos, Harry (author), Soudris, Dimitrios (author), Negrello, Mario (author), Strydis, C. (author)Modern neuroscience employs in silico experimentation on ever-increasing and more detailed neural networks. The high modeling detail goes hand in hand with the need for high model reproducibility, reusability and transparency. Besides, the size of the models and the long timescales under study mandate the use of a simulation system with high...journal article 2022
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Siddiqi, M.A. (author), Hahn, Georg (author), Hamdioui, S. (author), Serdijn, W.A. (author), Strydis, C. (author)A Medical Body Area Network (MBAN) is an ensemble of collaborating, potentially heterogeneous, medical devices located inside, on the surface of or around the human body with the objective of tackling one or multiple medical conditions of the MBAN host. These devices-which are a special category of Wireless Body Area Networks (WBANs)–collect,...journal article 2022
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Arvanitis, P. (author), Betting, Jan Harm L.F. (author), Bosman, Laurens W.J. (author), Al-Ars, Z. (author), Strydis, C. (author)Mice and rats can rapidly move their whiskers when exploring the environment. Accurate description of these movements is important for behavioral studies in neuroscience. Whisker tracking is, however, a notoriously difficult task due to the fast movements and frequent crossings and juxtapositionings among whiskers. We have recently developed...conference paper 2022
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Bauer, Staf (author), van Wingerden, Nathalie (author), Jacobs, Thomas (author), van der Horst, Annabel (author), Zhai, Peipei (author), Betting, Jan Harm L.F. (author), Strydis, C. (author), White, Joshua J. (author), De Zeeuw, Chris I. (author), Romano, Vincenzo (author)Neural activity exhibits oscillations, bursts, and resonance, enhancing responsiveness at preferential frequencies. For example, theta-frequency bursting and resonance in granule cells facilitate synaptic transmission and plasticity mechanisms at the input stage of the cerebellar cortex. However, whether theta-frequency bursting of Purkinje...journal article 2022
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Siddiqi, M.A. (author), Beurskens, Robert H.S.H. (author), Kruizinga, Pieter (author), De Zeeuw, Chris I. (author), Strydis, C. (author)Modern Implantable Medical Devices (IMDs) are vulnerable to security attacks because of their wireless connectivity to the outside world. One of the main security challenges is establishing trust between the IMD and an external reader/programmer in order to facilitate secure communication. Numerous device-pairing schemes have been proposed to...journal article 2021
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Siddiqi, M.A. (author), Serdijn, W.A. (author), Strydis, C. (author)The wireless capabilities of modern Implantable Medical Devices (IMDs) make them vulnerable to security attacks. One prominent attack, which has disastrous consequences for the patient’s wellbeing, is the battery Denial-of-Service attack whereby the IMD is occupied with continuous authentication requests from an adversary with the aim of...journal article 2020
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Betting, J.L.F. (author), Romano, Vincenzo (author), Al-Ars, Z. (author), Bosman, L.W.J. (author), Strydis, C. (author), De Zeeuw, Chris I. (author)Rodents engage in active touch using their facial whiskers: they explore their environment by making rapid back-and-forth movements. The fast nature of whisker movements, during which whiskers often cross each other, makes it notoriously difficult to track individual whiskers of the intact whisker field. We present here a novel algorithm,...journal article 2020
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Miedema, Rene (author), Smaragdos, Georgios (author), Negrello, Mario (author), Al-Ars, Z. (author), Möller, M. (author), Strydis, C. (author)The Hodgkin-Huxley (HH) neuron is one of the most biophysically-meaningful models used in computational neuroscience today. Ironically, the model's high experimental value is offset by its disproportional computational complexity. To such an extent that neuroscientists have either resorted to simpler models, losing precious neuron detail, or...journal article 2020
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Koekkoek, S. K.E. (author), Soloukeytbalvandany, S. (author), Generowicz, B.S. (author), Vanhoogstraten, W. S. (author), Deoude, N. L. (author), Boele, H. J. (author), Strydis, C. (author), Leus, G.J.T. (author), De Zeeuw, C. I. (author)Functional ultrasound (fUS) is a relatively new imaging modality to study the brain with a high spatiotemporal resolution and a wide field-of-view. In fUS detailed images of cerebral blood flow and volume are used to derive functional information, as changes in local flow and/or volume may reflect neuronal activation through neurovascular...conference paper 2018
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Smaragdos, Georgios (author), Chatzikonstantis, Georgios (author), Kukreja, Rahul (author), Sidiropoulos, Harry (author), Rodopoulos, Dimitrios (author), Sourdis, Ioannis (author), Al-Ars, Z. (author), Kachris, Christoforos (author), Soudris, Dimitrios (author), De Zeeuw, Chris I. (author), Strydis, C. (author)Objective. The advent of high-performance computing (HPC) in recent years has led to its increasing use in brain studies through computational models. The scale and complexity of such models are constantly increasing, leading to challenging computational requirements. Even though modern HPC platforms can often deal with such challenges, the...journal article 2017
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Kros, L. (author), Eelkman Rooda, O.H.J. (author), Spanke, J.K. (author), Alva, P. (author), Van Dongen, M.N. (author), Karapatis, A. (author), Tolner, E.A. (author), Strydis, C. (author), Davey, N. (author), Winkelman, B.H.J. (author), Negrello, M. (author), Serdijn, W.A. (author), Steuber, V. (author), Van den Maagdenberg, A.M.J.M. (author), De Zeeuw, C.I. (author), Hoebeek, F.E. (author)Objective Disrupting thalamocortical activity patterns has proven to be a promising approach to stop generalized spike-and-wave discharges (GSWDs) characteristic of absence seizures. Here, we investigated to what extent modulation of neuronal firing in cerebellar nuclei (CN), which are anatomically in an advantageous position to disrupt cortical...journal article 2015
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Strydis, C. (author)HEALTHCARE in the 21st century is changing rapidly. In advanced countries, in particular, healthcare is moving from a public to a more personalized nature. However, the costs of healthcare worldwide are increasing every year. Better use of technology can and should be used to get control of these costs. At the same time, implants have clearly...doctoral thesis 2011
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Strydis, C. (author), Gaydadjiev, G.N. (author)A more structured and streamlined design of implants is nowadays possible. In this paper we focus on implant processors located in the heart of implantable systems. We present a real and representative biomedical-application scenario where such a new processor can be employed. Based on a suitably selected processor simulator, various operational...journal article 2008