Spatial relationships in the urothelial and head and neck tumor microenvironment predict response to combination immune checkpoint inhibitors

Immune checkpoint inhibitors (ICI) can achieve remarkable responses in urothelial cancer (UC), which may depend on tumor microenvironment (TME) characteristics. However, the relationship between the TME, usually characterized by immune cell density, and response to ICI is unclear. Here, we quantify the TME immune cell densities and spatial...

Ergonomic Exoskeleton Synthesis: Application to a Wearable Passive Exoskeleton for the Shoulder

The human machine-interface is more important than ever in the field of exoskeletons. Current design approaches lack a way of systematically designing the ergonomics of exoskeletons. Methods with a more pro active approach to ergonomics have to be developed. This thesis extends existing methods by which self aligning mechanisms are created with...