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Schorsch, J.F. (author), Keemink, A.Q.L. (author), Stienen, A.H.A. (author), Van der Helm, F.C.T. (author), Abbink, D.A. (author)The design of exoskeletons is a popular and promising area of research both for restoring lost function and rehabilitation, and for augmentation in military and industrial applications. A major practical challenge to the comfort and usability for exoskeletons is the need to avoid misalignment of the exoskeletal joint with the underlying human...journal article 2014
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Reyes Reyes, A. (author), Hou, Z. (author), Van Mastrigt, E. (author), Horsten, R.C. (author), De Jongste, J.C. (author), Pijnenburg, M.W. (author), Urbach, H.P. (author), Bhattacharya, N. (author)We present a broadband quantum cascade laser-based spectroscopic system covering the region between 850 and 1250 cm?1. Its robust multipass cavity ensures a constant interaction length over the entire spectral region. The device enables the detection and identification of numerous molecules present in a complex gas mixture without any pre...journal article 2014
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Boogaard, F.C. (author), Lucke, T. (author), Van de Giesen, N.C. (author), Van de Ven, F.H.M. (author)Permeable pavements are a type of sustainable urban drainage system (SUDS) technique that are used around the world to infiltrate and treat urban stormwater runoff and to minimize runoff volumes. Urban stormwater runoff contains significant concentrations of suspended sediments that can cause clogging and reduce the infiltration capacity and...journal article 2014
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Janssen, D.M. (author), Sanders, A.P. (author), Guldemond, N.A. (author), Hermus, J. (author), Walenkamp, G.H. (author), Van Rhijn, L.W. (author)Background Hallux valgus deformity is a common musculoskeletal foot disorder with a prevalence of 3.5% in adolescents to 35.7% in adults aged over 65 years. Radiographic measurements of hallux valgus angles (HVA) are considered to be the most reproducible and accurate assessment of HVA. However, in European countries, many podiatrists do not...journal article 2014
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Valk, M. (author), Savenije, H.H.G. (author), Tiberius, C.C.J.M. (author), Luxemburg, W.M.J. (author)In this paper we present a novel method to determine the time of occurrence of tidal slack with a GPS receiver mounted on an anchored buoy commonly used to delineate shipping lanes in estuaries and tidal channels. Slack tide occurs when the tide changes direction from ebb to flood flow or from flood to ebb. The determination of this point in...journal article 2014
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Van der Put, T.A.C.M. (author)The results of an investigation of splitting of joints of [1] are used for a discussion of design methods and as necessary answer on comments and for confirmation of the extended fracture mechanics theory which accounts for the part of the external energy which is needed for plastic dissipation at the dowels, (which cause the crack opening). It...journal article 2014
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Van der Put, T.A.C.M. (author)The exact derivation of the mode I geometric correction factor is given, based on the small crack merging mechanism to show that this always is the real fracture mechanism in wood. This mechanism dominates at late softening and explains fully the apparent decrease of the energy release rate of macrocrack extension as already known for mode I and...journal article 2014
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Houwing-Duistermaat, J.J. (author), Helmer, Q. (author), Balliu, B. (author), Van den Akker, E.B. (author), Tsonaka, R. (author), Uh, H.W. (author)We have extended our recently developed 2-step approach for gene-based analysis to the family design and to the analysis of rare variants. The goal of this approach is to study the joint effect of multiple single-nucleotide polymorphisms that belong to a gene. First, the information in a gene is summarized by 2 variables, namely the empirical...journal article 2014
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Schmälter, A.K. (author), Kuzyk, A. (author), Righolt, C.H. (author), Neusser, M. (author), Steinlein, O.K. (author), Müller, S. (author), Mai, S. (author)Background Characterizing the nuclear orientation of chromosomes in the three-dimensional (3D) nucleus by multicolor banding (mBANDing) is a new approach towards understanding nuclear organization of chromosome territories. An mBANDing paint is composed of multiple overlapping subchromosomal probes that represent different regions of a single...journal article 2014
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Nemati, M. (author), Presura, C.N. (author), Urbach, H.P. (author), Bhattacharya, N. (author)Continuous health monitoring has become a major theme of our aging society. Portable devices play an important role here. Many optical portable devices are susceptible to motion induced artifacts. We have performed an experimental study for detection of fluid pulsation based on multi-exposure speckle images, in presence of motion induced...journal article 2014
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Euser, T. (author), Luxemburg, W.M.J. (author), Everson, C.S. (author), Mengistu, M.G. (author), Clulow, A.D. (author), Bastiaanssen, W.G.M. (author)The Bowen ratio surface energy balance method is a relatively simple method to determine the latent heat flux and the actual land surface evaporation. The Bowen ratio method is based on the measurement of air temperature and vapour pressure gradients. If these measurements are performed at only two heights, correctness of data becomes critical....journal article 2014
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Legrand, S. (author), Vanmeert, F. (author), Van der Snickt, G. (author), Alfeld, M. (author), De Nolf, W. (author), Dik, J. (author), Janssens, K. (author)The development of advanced methods for non-destructive selective imaging of painted works of art at the macroscopic level based on radiation in the X-ray and infrared range of the electromagnetic spectrum are concisely reviewed. Such methods allow to either record depth-selective, element-selective or species-selective images of entire...journal article 2014
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Gao, H. (author), Hrachowitz, M. (author), Fenicia, F.F. (author), Gharari, S. (author), Savenije, H.H.G. (author)Although elevation data are globally available and used in many existing hydrological models, their information content is still underexploited. Topography is closely related to geology, soil, climate and land cover. As a result, it may reflect the dominant hydrological processes in a catchment. In this study, we evaluated this hypothesis...journal article 2014
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Vollebergh, M.A. (author), Lips, E.H. (author), Nederlof, P.M. (author), Wessels, L.F.A. (author), Wesseling, J. (author), Van de Vijver, M.J. (author), De vries, E.G.E. (author), Van Tinteren, H. (author), Jonkers, J. (author), Hauptman, M. (author), Rodenhuis, S. (author), Linn, S.C. (author)Introduction: BRCA-mutated breast cancer cells lack the DNA-repair mechanism homologous recombination that is required for error-free DNA double-strand break (DSB) repair. Homologous recombination deficiency (HRD) may cause hypersensitivity to DNA DSB-inducing agents, such as bifunctional alkylating agents and platinum salts. HRD can be caused...journal article 2014
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Suarez-Mendez, C.A. (author), Sousa, A. (author), Heijnen, J.J. (author), Wahl, S.A. (author)Microorganisms are constantly exposed to rapidly changing conditions, under natural as well as industrial production scale environments, especially due to large-scale substrate mixing limitations. In this work, we present an experimental approach based on a dynamic feast/famine regime (400 s) that leads to repetitive cycles with moderate changes...journal article 2014
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Molin, E.J.E. (author), Van den Bos, G. (author)Intelligent Speed Adaptation (ISA), an in-vehicle system that can either warn the driver or directly limit the vehicle’s speed when the speed limit is reached, is generally believed to have a large potential to increase road safety. However, policy makers hesitate to take policy measures that may increase ISA use. Public acceptance of ISA or...journal article 2014
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Kloosterman, A. (author), Hierck, B. (author), Westerweel, J. (author), Poelma, C. (author)Since fluid dynamics plays a critical role in vascular remodeling, quantification of the hemodynamics is crucial to gain more insight into this complex process. Better understanding of vascular development can improve prediction of the process, and may eventually even be used to influence the vascular structure. In this study, a methodology to...journal article 2014
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Van Vliet, S. (author), Hol, F.J.H. (author), Weenink, T. (author), Galajda, P. (author), Keymer, J.E. (author)Background Bacterial habitats, such as soil and the gut, are structured at the micrometer scale. Important aspects of microbial life in such spatial ecosystems are migration and colonization. Here we explore the colonization of a structured ecosystem by two neutrally labeled strains of Escherichia coli. Using time-lapse microscopy we studied the...journal article 2014
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Bajaj, I. (author), Veiga, T. (author), Van Dissel, D. (author), Pronk, J.T. (author), Daran, J.M. (author)Background Microbial gene expression is strongly influenced by environmental growth conditions. Comparison of gene expression under different conditions is frequently used for functional analysis and to unravel regulatory networks, however, gene expression responses to co-cultivation with other microorganisms, a common occurrence in nature, is...journal article 2014
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Righolt, C.H. (author), Mai, S. (author), Van Vliet, L.J. (author), Stallinga, S. (author)The quality of the reconstructed image in structured illumination microscopy (SIM) depends on various aspects of the image filtering process. To optimize the trade-off between resolution and ringing artifacts, which lead to negative intensities, we extend Lukosz-bound filtering to 3D SIM and derive the parametrization of the 3D SIM cut-off. We...journal article 2014