Transfer-free Fabrication and Assessment of Transparent Multilayer CVD Graphene MEAs for in-vitro Optogenetic Studies

Electronic interfaces, particularly microelectrode arrays (MEAs), are crucial for studying electrophysiological processes in the body, with applications ranging from implants to deep brain simulators. In neuroscience, they play a vital role in exploring neuronal cell distribution and behaviour, as well as disorders like epilepsy and Alzheimer’s...

Organ-on-Chip Platform with Transient Membrane for Vascularisation of Brain Organoids

<br/>Organ-on-Chip (OoC) is a technology that aims to increase the efficiency of drug development processes and organ models by engineering well-defined cell culture environments. Physiological relevant mechanical, chemical, or electrical cues provide in vivo-like microenvironments for realistic cell maturation. Biodegradable technologies have...

Pressure monitoring inside the nozzle of a fused filament fabrication (FFF) 3D printer

Fused filament fabrication (FFF) is the most used additive manufacturing technique that uses a heated nozzle to melt a polymer and a feeder to extrude it on a buildplate. The dependencies of temperature, shear-rate, viscosity and pressure of the melt create complex dynamics within the nozzle, which causes inconsistent extrusion. To improve...

Influence of Automated Fiber Placement in Fused Deposition Modelling with reinforced thermoplastic materials

Fused deposition modeling (FDM) is one of the fastest-growing additive manufacturing processes in recent years. Nevertheless, the mechanical properties cannot be matched to those of traditional manufacturing methods such as injection molding.The research presented in this report aims to demonstrate the limitations of fusion deposition models and...

Large bone-implants for osteochondral regeneration, fabrication and ex-vivo testing

The high frequency of osteoarthritis in those aged above 60 years combined with the observing trend of overpopulation leads to increased healthcare costs. To date, clinical treatments seem to be insufficient to restore cartilage and underlying bone degeneration. Bioprinting fabrication techniques constitute a promising approach to mimic and...