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Braem, Sarah (author)
Drug efficacy and side effects are significantly impacted by the first-pass metabolism, a sequence of events that occurs in the stomach and the liver after oral ingestion. Accurate prediction of this mechanism is crucial for a faster and more cost-efficient drug development process. Replicating the first-pass metabolism in vitro using standard...
master thesis 2023
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van der Voort, Silvana (author)
Biomedical micro-electromechanical systems or BioMEMS are microdevices with actuation or sensory function in biomedical applications. In this process, polymers are widely used as material layers. Polymers have significant advantages for applications in BioMEMS, such as low cost and ease of fabrication.<br/>The problem at the moment is the lack...
master thesis 2022
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R KANNAN, Shirley (author)
Organs-on-Chips (OoCs) are micro-engineered devices in which small samples of human-organ tissue are cultured on the substrate. A chip is designed in such a way that it can emulate the in-vivo physiological environment for disease modeling and drug screening. OoC technology can be incorporated into the drug development process from early drug...
master thesis 2022
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Lolla, Sai Sandeep (author)
Implantable Medical Devices (IMDs) offer a wide range of applications including but not limited to blood pressure monitoring, bladder pressure sensing, glucose level monitoring, neurostimulation etc. For such applications, it is often desired that an IMD is as small as possible while meeting the required objective. Consequently, using a battery...
master thesis 2022
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Hintzen, Annemijn (author)
Elongated mechanical ventilation is associated with ventilator-induced lung injury (VILI), diaphragmatic muscle atrophy, patient discomfort, increased mortality rates and higher healthcare costs. However, hospitals are lacking in user-friendly, affordable and accurate methods to measure the decline the respiratory condition. Computed tomography ...
master thesis 2022
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Angenent, Maricke (author)
Cardiorenal Syndrome (CRS) is a multi-organ disease characterized by a reciprocal pathological interaction between the heart and kidneys during acute or chronic injury. Yet, a complete understanding of the underlying bi-directional pathophysiological mechanisms is lacking, hence obscuring effective diagnostic strategies, patient stratification...
master thesis 2022
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Yeh, Jia-Jun (author)
Particle sorting is an important step in many biological and biomedical techniques. One sorting technique that has received a lot of attention is based on acoustophoresis. Manipulating cells with acoustic forces allows for a sorting method based on physical properties in a non-invasive, label-free, and biocompatible manner. To date, acoustic...
master thesis 2022
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Subramaniam, Indulakshmi (author)
Active implantable devices are conventionally powered with batteries. The miniaturisation of implants necessitates the need to find an efficient way to transfer power wirelessly. Ultrasound energy transfer with its short wavelength, small receiving transducer size, beamforming capability makes deep tissue penetration possible making it a good...
master thesis 2021
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Shriya Rangaswamy, Shriya (author)
The lack of reliable disease models hampers the development of safe and effective drugs for humansas they fail to precisely identify the cardiotoxicity profile of drug compounds. Recent technological advancements have led to the development of the"Organ-On-Chip"(OOC) technology. OOCs are miniaturized micro-engineered devices which aim to...
master thesis 2021
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Amesz, Jorik (author)
Cardiac mapping techniques, in which an electrode-array is placed directly on the surface of the heart, were developed to gain a better insight in the underlying electropathology of cardiac arrhythmias. This procedure is performed in patients undergoing cardiac surgery, but here not all relevant cardiac structures and conduction inquiries can be...
master thesis 2020
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Malek Kani, Sevda (author)
The application of implantable medical devices (IMDs) is increasing rapidly due to the many health benefits they provide in diagnosing and treating diseases. However, these devices have to be able to survive harsh body conditions to ensure their reliability and functionality. Bodily fluids initiate chemical degradation and corrosion in the...
master thesis 2020
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Westhoek, Youri (author)
Implantable medical devices (IMDs) such as cardiac pacemakers, cochlear implants, and neurostimulators improve millions of people’s lives every day. Over the years, IMDs have significantly improved in function, increased in lifetime, and decreased in size. However, further miniaturisation is limited by the batteries used to power these devices,...
master thesis 2020
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Teye, Joshua (author)
Diagnostic imaging is a fundamental requirement for the effective treatment of about 25 % of patients globally. Ultrasound imaging is considered the safest, least expensive and most convenient diagnostic imaging modality. Its widespread adoption has been in the area of 2D imaging. However, the accuracy of diagnosis with 2D ultrasound imaging is...
master thesis 2020
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Sluijs, J. (author)
Crack growth is an important failure mechanism in many engineering materials. Numerical models for crack growth have been developed within the framework of damage mechanics. All these models aim for the same goal, obtaining accurate results for crack growth under various loading conditions. Many damage models are based upon the cohesive crack...
master thesis 2020
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Safai, Eric (author)
Isolation of specific biological phenomena in vitro is critical to understanding living systems, due to cells’ innate capacity to integrate and respond to a wide range of signals simultaneously. Concomitantly, advances in micromanufacturing techniques overlap with progress in tissue engineering to produce microenvironments that better mimic in...
master thesis 2020
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Saccher, Marta (author)
During the past decade, Implantable biomedical devices have emerged as an efficient treatment for neurological disorders. Among them, low-intensity focused ultrasound (LIFU) has recently gained interest due to its focusing ability, depth of penetration and reversible effects. Although the exact biophysical mechanism that leads to the interaction...
master thesis 2019
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Wu, Diane (author)
The Flex-to-Rigid (F2R) platform is a generic IC-based technology platform that allows flexible sensors and electronics to be fabricated and integrated onto the catheters or guidewires of minimally invasive medical instruments. In this thesis, a process flow was developed for the fabrication of flexible metal interconnects based on the F2R...
master thesis 2018
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Mastyani, Hanieh (author)
The process of generating new therapeutics is a complex, highly demanding, and economically challenging procedure. From every 10.000 drug candidates that are introduced to the preclinical phase, only 5 are chosen to be tested for clinical trials. In order to overcome the challenges with current drug screening and toxicity tests, Organ-On-Chip ...
master thesis 2018
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Muhammad Hanif Nadhif, Hanif (author)
The use of conventional biological assay tools, such as Petri dish, has hindered the drug discovery studies ineffective and time-consuming. To cope with this problem, organ-on-chip (OOC) devices have been developed. Modeling organ functionality, topography, and pathology, OOC devices are expected to pave the way the drug discovery processes....
master thesis 2018
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Affan Kaysa Waafi, Affan (author)
Organ-on-Chips (OOCs) are micro-fabricated devices that combine micro-engineering with in-vitro cell culturing. This combination results in an in-vitro model that mimics the minimal functional unit of a human organ. OOC devices are expected to provide accurate and predictive screening tools that will eventually reduce false negatives and false...
master thesis 2018
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