The plasma membrane: Nature's touch screen?

Nanotopography has the ability to induce osteogenic differentiation of human Mesenchymal Stem Cells (hMSCs) without the addition of chemical supplements. Understanding of the early mechanisms that interact at the membrane-topography interface and subsequently induce the osteogenic differentiation of hMSCs as a result of nanotopography is key to...

Surface-cell interactions: Can PEO topography outsmart surface calcium?

Titanium surfaces modified by plasma electrolytic oxidation (PEO) have attractive physico-chemical characteristics that may favor osseointegration of bone implants. This study aimed at delineating the effects of PEO topography and surface calcium on the in vitro pre-osteoblasts response. Two different surfaces were generated by varying the...

Nitinol Drug Eluting Surfaces for Coronary Stents

Nowadays, drug eluting stents (DES) are the treatment of choice for de novo atherosclerotic lesions. Novel DES are shifting to polymer-free (PF) drug delivery in order to avoid the problem of late stent thrombosis associated with long term polymer presence in the vessel lumen. The scope of this study was to assess the potential of a microporous...

The response of SV-HFO cells to Ti6Al7Nb surfaces modified by Plasma Electrolytic Oxidation

The aim of this study was to assess the response of preosteoblasts (SV-HFO), from adhesion to matrix mineralization, on Ti6Al7Nb surfaces modified by plasma electrolytic oxidation (PEO). Two different surfaces have been generated by changing the oxidation duration from 1 to 5 minutes. The resultant (PEO1 and PEO5) surfaces showed uniform porous...