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Kruithof, Odin (author)
With FLASH proton radiotherapy, healthy tissue is spared more compared to conventional proton therapy. The FLASH effect is present at high fractional doses of more than 8 Gy, at ultra-high mean dose rates of more than 40 Gy per second and at dose delivery times of less than 200 milliseconds. However, particle accelerator intrinsic uncertainties...
master thesis 2023
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van Zon, Manon (author)
Intensity modulated proton therapy is an advanced radiotherapy technique that is used to treat cancer patients. In order to successfully treat a patient, sufficient dose to the tumor is required. However, during the fractionated treatment, multiple errors can cause a difference between the planned and actual dose delivery. To ensure adequate...
master thesis 2023
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Goudriaan, Sven (author)
Proton irradiation therapy is a powerful form of cancer treatment, promising better dose conformity as compared to conventional radiotherapy. Due to the complex scattering properties of protons, the optimization process that is needed to accurately target the cancer cells whilst causing minimal damage to<br/>the surrounding healthy tissue and...
bachelor thesis 2023
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Spek, Bob (author)
Over 50% of cancer patients will receive radiotherapy treatment at least once. Most patients are receiving photon radiotherapy. In this work very high energy electron (VHEE) radiotherapy is being studied as a potential replacement for photon radiotherapy. VHEE beams have a favorable depth dependence and the penumbra of VHEE pencil beams stays...
master thesis 2023
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van Dijk, Chris (author)
The Molten Salt Fast Reactor (MSFR) is a next generation nuclear reactor. The MSFR may play an important role in combatting global warming whilst ensuring energy safety considering fossil fuels’ finiteness. A key safety mechanism for the MSFR is the freeze plug, a valve underneath the reactor core designed to melt during reactor malfunction,...
master thesis 2023
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Maasland, Anouk (author)
The aim of this thesis is to study the dosimetric feasibility of FLASH proton therapy for early-stage breast cancer patients. The biological effect of FLASH is seen under ultra-high dose-rates conditions and is beneficial in the damage to healthy tissue. The FLASH effect could enable the clinical feasibility of definitive radiotherapy for low...
master thesis 2022
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Verburg, Corné (author)
This work aims at finding a second order accurate level-set method which solves the Stefan problem with non-homogeneous Dirichlet boundary conditions in one dimension. The numerical accuracy of the FTCS-scheme, BTCS-scheme and Crank-Nicolson scheme for the discretization of the heat equation was considered, as well as the accuracy of the first...
bachelor thesis 2021
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Oppelaar, Pieter (author)
In this report, the conversion from spin-echo signals, obtained with a low-field hand-held MRI scanner that was designed and built at the Leiden University, to images of the proton density within the sample is considered. This scanner does not make use of switchable gradient coils, but instead relies solely on the natural inhomogeneity of the...
bachelor thesis 2021
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Meijer, Angeline (author)
FLASH proton therapy is a growing field of research, especially due to its biological benefits in radiation oncology: sparing healthy tissue while delivering the treatment within a millisecond. However, instead of sparing healthy tissue, the conventional FLASH approach, using transmission beams, damages the tissue behind the...
master thesis 2021
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van den Bos, Joshua (author)
In this thesis, a new methodology called the adjoint method is developed to select an optimal set of beam angles and beam weights in external beam radiotherapy. The Linear Boltzmann Transport Equation is specifically adjusted for proton transport and forms the Fokker-Planck approximation. The Fokker-Planck approximation models proton transport....
master thesis 2021
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Akkerman, David (author)
SPECT is a nuclear medical imaging technique which measures the distribution of a radioactive agent in the human body. Because the scan data is available only on the boundary of the system, it is challenging to determine from which location a measured photon originated. In this research PDE-constrained optimization methods are used to determine...
master thesis 2021
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Ibrahimi, Atia (author)
As protons have a localized depth-dose distribution, proton therapy nowadays is a form of radiotherapy that is being implemented for part of the cancer patients. Compared to photon therapy it allows more precise targeting of tumours and sparing of surrounding healthy tissue. Besides patient treatment, research on proton therapy topics is being...
master thesis 2020
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Steinebach, Koen (author)
In proton therapy, robust treatment planning is currently used to account for uncertainties in patient alignment and proton beam range. A way to overcome the limitations of robust treatment planning is to use probabilistic treatment planning, which can be computationally expensive due to the calculations of statistical measures of stochastic...
master thesis 2020
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Dijkstra, Jasper (author)
Very high energy electron (VHEE) radiotherapy is being investigated as a potential replacement of photon therapy. VHEE pencil beams have a small penumbra and strong depth dependence for radiotherapy when compared to photons. This allows a lower dose to healthy tissue. Generating these high electron energy beams could be...
master thesis 2020
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Rituerto Prieto, Henar (author)
The main challenge of radiotherapy, used for treating cancer, is to deposit the prescribed dose in the tumor volume while sparing the surrounding tissue.The depth-dose distribution of protons makes proton therapy an alternative to conventional radiotherapy for some tumor sites. A better knowledge of the proton radiobiological mechanisms can...
master thesis 2020
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Wendt, S.M.A. (author)
master thesis 2020
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Groen, Jort (author)
Radiotherapy (RT) is an important modality in treatment against cancer. Developments in this modality are necessary for improvement of patient complications and survival. Aside from fractionation and precise irradiation, FLASH radiotherapy could be a third way to significantly increase the therapeutic window of radiotherapy.The FLASH effect is a...
master thesis 2020
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Swart, Jonathan (author)
A visible tumor can be surrounded by invisible groups of cancer cells called microscopic disease that cannot be imaged. For ultimate tumor control it is imperative that not only the visible tumor, but also this microscopic disease is irradiated. In current clinical practice, microscopic disease control is achieved by not just irradiating the...
bachelor thesis 2020
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Francke, Age (author)
The purpose of this research is to investigate how much we are able to improve the reconstruction of images from a low-cost MRI-scanner prototype aimed to be employed in developing countries. We used a data-driven approach searching for linear combinations of signals from a small measured data-set to form reconstructed images. This was done by...
bachelor thesis 2020
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kleyn Winkel, Lars (author)
The goal of this project is to see if we can improve the treatment plan for proton therapy by using reduced order models and adjoint theory for proton therapy. We shall use a singular value decomposition on a dose distribution matrix to obtain the modes from which we can reconstruct every dose distribution. Using adjoint methodologies for proton...
bachelor thesis 2019
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