Semi-stochastic cell-level computational modelling of cellular forces

A phenomenological model is formulated to model cellular forces on extracellular material. The model is capable of modelling both expansion and contractile forces. This work is based on the assumption of linear elasticity, which allows a superposition argument to arrive at fundamental expressions for cellular forces. It is also shown how the...

A semi-stochastic cell-based formalism to model the dynamics of migration of cells in colonies

We consider the movement and viability of individual cells in cell colonies. Cell movement is assumed to take place as a result of sensing the strain energy density as a mechanical stimulus. The model is based on tracking the displacement and viability of each individual cell in a cell colony. Several applications are shown, such as the dynamics...