Acceleration of read alignment with coherent attached FPGA coprocessors

With the advent of Next Generation Sequencing (NGS), the cost of sequencing human DNA has decreased significantly over the past decade. This decrease in cost has attracted a great deal of attention from medical research and is now transitioning to clinical practice. Precision medicine, tailored to a persons's genetic profile, is becoming a...

Low-Cost Smith-Waterman Acceleration

Due to advancing technology, genetic sequencing has become cheaper over the years. This has caused the demand for computational power to grow even faster than Moore's law. To remedy this problem, we analyzed low-cost hardware solutions to parallelize the computational part of the genetic sequencing. We proposed a novel method for calculating the...

Biological Sequence Alignment Using Graphics Processing Units

Alignment algorithms are used to find similarity between biological sequences, such as DNA and proteins. By aligning a sequence with a database, similar sequences can be found. These can be used to identify the source of a query sequence, to find commonalities between organisms, or to infer an ancestral relation. Various methods of performing...