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Bomer, N. (author), Den Hollander, W.T.H.F. (author), Ramos, Y.F.M. (author), Bos, S.D. (author), Van der Breggen, R. (author), Lakenberg, N. (author), Pepers, B.A. (author), Van Eeden, A.E. (author), Darvishan, A. (author), Tobi, E.W. (author), Duijnisveld, B.J. (author), Van den Akker, E.B. (author), Heijmans, B.T. (author), Van Roon-Mom, W.M.C. (author), Verbeek, F.J. (author), Osch, G.J.V.M. (author), Nelissen, R.G.H.H. (author), Slagboom, P.E. (author), Meulenbelt, I. (author)Objectives: To investigate how the genetic susceptibility gene DIO2 confers risk to osteoarthritis (OA) onset in humans and to explore whether counteracting the deleterious effect could contribute to novel therapeutic approaches. Methods: Epigenetically regulated expression of DIO2 was explored by assessing methylation of positional CpG...journal article 2015
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- Passtoors, W.M. (author), Van den Akker, E.B. (author), Deelen, J. (author), Maier, A.B. (author), Van der Breggen, R. (author), Jansen, R. (author), Trompet, S. (author), Van Heemst, D. (author), Derhovanessian, E. (author), Pawelec, G. (author), Van Ommen, G.J.B. (author), Slagboom, P.E. (author), Beekman, M. (author) journal article 2015
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Passtoors, W.M. (author), Boer, J.M. (author), Goeman, J.G. (author), Van den Akker, E.B. (author), Deelen, J. (author), Zwaan, B.J. (author), Scarborough, A. (author), Van der Breggen, R. (author), Vossen, R.H.A.M. (author)The Leiden Longevity Study consists of families that express extended survival across generations, decreased morbidity in middle-age, and beneficial metabolic profiles. To identify which pathways drive this complex phenotype of familial longevity and healthy aging, we performed a genome-wide gene expression study within this cohort to screen for...journal article 2012