Improved control of an IV administration system

Intravenous therapy is the most common way for the delivery of substances to (hospitalized) patients. The amount of patients receiving some form of Intravenous (IV) therapy is enormous (85−90%). Different techniques exist for the administration of IV fluids. The two main administration techniques are: active (pump based) and passive (gravity...

Wireless Power Transfer and Optogenetic Stimulation of Freely Moving Rodents

Animal studies are commonly used to test the feasibility and effectiveness of promising novel neu- roscience research ideas. One such new technique is optogenetic stimulation, a state-of-the-art brain stimulation technique. In optogenetics, genetic techniques are used to create light-sensitive proteins within the neuron membrane, thus allowing...

Generating CRISPR-dCas9 System in Clostridium difficile Bacteria

The increasing incidence of Clostridium difficile-associated disease, and its resistance to a number of antibiotics, highlight the need for additional countermeasures. The main issue that hampers the design of antibiotics is a lack of appropriate tools to study the molecular biology of C.difficile in great detail. Insight into the function of...

Application of ultrasound to remove thrombi from the Left ventricular assist device

Due to limited number of donor hearts and stringent eligibility criteria for heart transplant the Left ventricular assist device (LVAD) has emerged as a relevant treatment option for heart failure. Occlusion in the form of a thrombus (blood clot) is a feared complication associated with the LVAD. The ability of ultrasound to result in effects...

Smart wound patch: Design of an integrated electronic sensor system for continuous wound monitoring

Worldwide ca. 20 million patients are suffering from slow- or non-healing wounds. These problematic wounds have a major impact on the mortality risk, quality of life and mobility of patients. Moreover, non-healing wounds are a major financial burden for health care providers. Currently, wound treatments are selected mainly based on visual...

Fabrication and characterization of an Upside-down CNT MEA

Over the last few years the need of new alternatives to traditional disease modelling, drug screening and toxicity tests has boosted the development of a new class of devices called Organ on Chip. These usually consist in a substrate or a well in which cells are cultured with the aim of differentiating them in a particular tissue lineage. With...