3D-Engineered Scaffolds to Study Microtubes and Localization of Epidermal Growth Factor Receptor in Patient-Derived Glioma Cells

A major obstacle in glioma research is the lack of in vitro models that can retain cellular features of glioma cells in vivo. To overcome this limitation, a 3D-engineered scaffold, fabricated by two-photon polymerization, is developed as a cell culture model system to study patient-derived glioma cells. Scanning electron microscopy, (live...

3D Engineered Glioblastoma Microenvironments for Proton Beam Irradiation

Glioblastoma (GBM) is a devastating cancer of the brain with an extremely poor prognosis. Novel <i>in-vitro</i> methods for the assessment of cancer response to drugs and radiation are being developed. Compared to two-dimensional cell culture, three-dimensional cellular microenvironments provide a model closer to the <i>in-vivo</i> situation. In...