Atomic and Molecular Layer Deposition for Controlled Drug Delivery

The majority of pharmaceutical products is made of solid powders. The morphology and surface characteristics of drug particles affect both their bulk behaviour, e.g., flowability, dispersibility and tabletability, in the manufacturing process of dosage forms as well as their bioavailability upon administration into the human body. For instance,...

Controlled Pulmonary Delivery of Carrier-Free Budesonide Dry Powder by Atomic Layer Deposition

Ideal controlled pulmonary drug delivery systems provide sustained release by retarding lung clearance mechanisms and efficient lung deposition to maintain therapeutic concentrations over prolonged time. Here, we use atomic layer deposition (ALD) to simultaneously tailor the release and aerosolization properties of inhaled drug particles...

Drug powders with tunable wettability by atomic and molecular layer deposition: From highly hydrophilic to superhydrophobic

The wettability of pharmaceuticals is a key physical property which influences their dissolution rate, dispersibility, flowability and solid-state stability. Here, we provide a platform of surface nanoengineering methods capable of tuning the wettability of drug powders from high hydrophilicity to superhydrophobicity with drug loadings up to...