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Li, Bo (author), Niessen, W.J. (author), Klein, Stefan (author), de Groot, Marius (author), Ikram, M. Arfan (author), Vernooij, Meike W. (author), Bron, Esther E. (author)This work presents a single-step deep-learning framework for longitudinal image analysis, coined Segis-Net. To optimally exploit information available in longitudinal data, this method concurrently learns a multi-class segmentation and nonlinear registration. Segmentation and registration are modeled using a convolutional neural network and...journal article 2021
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Li, Bo (author), de Groot, Marius (author), Steketee, Rebecca M.E. (author), Meijboom, Rozanna (author), Smits, Marion (author), Vernooij, Meike W. (author), Ikram, M. Arfan (author), Liu, Jiren (author), Niessen, W.J. (author)Subtle changes in white matter (WM) microstructure have been associated with normal aging and neurodegeneration. To study these associations in more detail, it is highly important that the WM tracts can be accurately and reproducibly characterized from brain diffusion MRI. In addition, to enable analysis of WM tracts in large datasets and in...journal article 2020
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Vinke, Elisabeth J. (author), de Groot, Marius (author), Venkatraghavan, Vikram (author), Klein, S. (author), Niessen, W.J. (author), Ikram, M. Arfan (author), Vernooij, Meike W. (author)With aging, the brain undergoes several structural changes. These changes reflect the normal aging process and are therefore not necessarily pathologic. In fact, better understanding of these normal changes is an important cornerstone to also disentangle pathologic changes. Several studies have investigated normal brain aging, both cross...journal article 2018
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Chaker, Layal (author), Cremers, Lotte G M (author), Korevaar, Tim I.M. (author), De Groot, Marius (author), Dehghan, Abbas (author), Franco, Oscar H. (author), Niessen, W.J. (author), Ikram, M. Arfan (author), Peeters, Robin P. (author), Vernooij, Meike W. (author)Thyroid hormone (TH) is crucial during neurodevelopment, but high levels of TH have been linked to neurodegenerative disorders. No data on the association of thyroid function with brain imaging in the general population are available. We therefore investigated the association of thyroid-stimulating hormone and free thyroxine (FT4) with...journal article 2018
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Evans, Tavia E. (author), O'Sullivan, Michael J. (author), De Groot, Marius (author), Niessen, W.J. (author), Hofman, Albert (author), Krestin, Gabriel P. (author), Van Der Lugt, Aad (author), Portegies, Marileen L P (author), Koudstaal, Peter J. (author), Bos, Daniel (author), Vernooij, Meike W. (author), Ikram, M. Arfan (author)Background and Purpose - The presence of subclinical vascular brain disease, including white matter lesions and lacunar infarcts, substantially increases the risk of clinical stroke. White matter microstructural integrity is considered an earlier, potentially better, marker of the total burden of vascular brain disease. Its association with...journal article 2016
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Ikram, M.A. (author), Van der Lugt, A. (author), Niessen, W.J. (author), Koudstaal, P.J. (author), Krestin, G.P. (author), Hofman, A. (author), Bos, D. (author), Vernooij, M.W. (author)Imaging plays an essential role in research on neurological diseases in the elderly. The Rotterdam Scan Study was initiated as part of the ongoing Rotterdam Study with the aim to elucidate the causes of neurological disease by performing imaging of the brain in a prospective population-based setting. Initially, in 1995 and 1999, random...journal article 2015
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Ikram, M.A. (author), Van der Lugt, A. (author), Niessen, W.J. (author), Krestin, G.P. (author), Koudstaal, P.J. (author), Hofman, A. (author), Breteler, M.M.B. (author), Vernooij, M.W. (author)Neuroimaging plays an important role in etiologic research on neurological diseases in the elderly. The Rotterdam Scan Study was initiated as part of the ongoing Rotterdam Study with the aim to unravel causes of neurological disease by performing neuroimaging in a population-based longitudinal setting. In 1995 and 1999 random subsets of the...journal article 2011
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De Boer, R. (author), Schaap, M. (author), Van der Lijn, F. (author), Vrooman, H.A. (author), De Groot, M. (author), Van der Lugt, A. (author), Ikram, M.A. (author), Vernooij, M.W. (author), Breteler, M.M.B. (author), Niessen, W.J. (author)Diffusion MRI can be used to study the structural connectivity within the brain. Brain connectivity is often represented by a binary network whose topology can be studied using graph theory. We present a framework for the construction of weighted structural brain networks, containing information about connectivity, which can be effectively...journal article 2010