Chlorination contributes to multi-antibiotic resistance in a pilot-scale water distribution system

The generation and dissemination of antibiotic resistance bacteria (ARB) and antibiotic resistance genes (ARGs) in the environment has become a critical risk to human health. This study is based on a pilot-scale simulated water distribution system to understand the effects of chlorine disinfection treatment (without free chlorine) on ARB and...

Mycobacterium tuberculosis Whole Genome Sequences From Southern India Suggest Novel Resistance Mechanisms and the Need for Region-Specific Diagnostics

Background.<br/><br/>India is home to 25% of all tuberculosis cases and the second highest number of multidrug resistant cases worldwide. However, little is known about the genetic diversity and resistance determinants of Indian Mycobacterium tuberculosis, particularly for the primary lineages found in India, lineages 1 and 3.<br/>Methods.<br/>...

Detecting mixed Mycobacterium tuberculosis infections and differences in drug susceptibility with WGS data

Tuberculosis is a pulmonary disease caused by the pathogen Mycobacterium tuberculosis and is the second leading cause of death from an infectious disease. Individuals infected by multiple strains referred to as a mixed infection are associated with poor treatment outcomes when the infecting strains differ in their susceptibility against...