Reliable Offine Policy Evaluation for Individualized Mechanical Ventilation

Individualizing mechanical ventilation treatment regimes remains a challenge in the intensive care unit (ICU). Reinforcement Learning (RL) offers the potential to improve patient outcomes and reduce mortality risk, by optimizing ventilation treatment regimes. We focus on the Offline RL setting, using Offline Policy Evaluation (OPE), specifically...

Towards more credible models in catchment hydrology to enhance hydrological process understanding: Preface

Catchment modelling has undergone tremendous developments during the past decades. In the 1970s, the focus was on simulation of catchment runoff with process descriptions and data inputs being lumped to the catchment scale. Later developments included spatially distributed models allowing data inputs and hydrological processes to be simulated at...

A comparison of alternative multiobjective calibration strategies for hydrological modeling

A conceptual hydrological model structure contains several parameters that have to be estimated through matching observed and modeled watershed behavior in a calibration process. The requirement that a model simulation matches different aspects of system response at the same time has led the calibration problem toward a multiobjective approach....

Theoretical and practical aspects of modelling activated sludge processes

This thesis describes the full-scale validation and calibration of a integrated metabolic activated sludge model for biological phosphorus removal. In chapters 1 and 2 the metabolic model is described, in chapters 3 to 6 the model is tested and in chapters 7 and 8 the model is put into practice. Chapter 1 is a general introduction to this...