Ultrasmall Gold Nanoparticles Radiolabeled with Iodine-125 as Potential New Radiopharmaceutical

The relatively high linear energy transfer of Auger electrons, which can cause clustered DNA damage and hence efficient cell death, makes Auger emitters excellent candidates for attacking metastasized tumors. Moreover, gammas or positrons are usually emitted along with the Auger electrons, providing the possibility of theragnostic...

Theoretical investigation on the effect of volume fraction in the optical trapping of gold nanoparticles

Stable optical trapping of gold nanoparticles is essential and desirable because of its wide applications in nanotechnology. While several factors have been proposed to affect optical trapping stability, the sample's volume fraction during optical trapping has often been neglected. To address this, by utilizing the effective medium theory, we...

Synthesis of ^197m/gHg labelled gold nanoparticles for targeted radionuclide therapy

Meitner-Auger-electron emitters have a promising potential for targeted radionuclide therapy of cancer because of their short range and the high linear energy transfer of Meitner-Auger-electrons (MAE). One promising MAE candidate is 197m/gHg with its half-life of 23.8 » h and 64.1 » h, respectively, and high MAE yield. Gold nanoparticles ...

Plasmon resonance spectral peak shift due to morphing of gold nanoparticles for strain sensing

The plasmon resonance spectral peak of a gold spherical nanoparticle (NP) will shift when the NP shape is changed from sphere to spheroid. This may be used as a novel strain detection method with gold NPs embedded in a medium of different refractive index (RI). Applying a strain to the external medium will cause a change in the shape of the...

Core–shell structured gold nanoparticles as carrier for ¹⁶⁶Dy/¹⁶⁶Ho in vivo generator

Background: Radionuclide therapy (RNT) has become a very important treatment modality for cancer nowadays. Comparing with other cancer treatment options, sufficient efficacy could be achieved in RNT with lower toxicity. β⁻ emitters are frequently used in RNT due to the long tissue penetration depth of the β⁻ particles....

Plasmon resonance based gold nanoparticle doped optical fibre strain sensing

Strain-based structural health monitoring (SHM) relies on high performance strain sensing methods. Gold nanoparticle (NP) doped fibre optic sensors not only have the potential to increase the intensity of the backscattered signal to increase the signal to noise ratio but also have plasmon resonance peaks in the visible light range. The...

Light scattering by gold nanoparticles cured in optical adhesive at optical fibre interfaces

This study forms a part of the research in using nanoparticles (NPs) to increase the intensity of light scattering signal in the optical fibres. Increasing the intensity of the backscattered light signal in the optical fibres shows the potential to increase the signal-to-noise ratio in order to improve the sensitivity of the backscatter...

Modelling of light scattering by gold nanoparticles at optical fibre interfaces

Optical fibre backscatter reflectometry is an important technique for Structural Health Monitoring (SHM). In recent years, increasing the intensity of backscattered light in backscatter reflectometry has shown the advantage of improving the signal detection in shape sensing and temperature detection due to the increase of signal to noise...

Solvent-free oxidation of 1-phenylethanol catalysed by gold nanoparticles supported on carbon powder materials

Gold (1 wt.%) was loaded on several carbon materials, namely, polymer based carbon xerogel, activated carbon, microdiamonds, nanodiamonds, graphite and silicon carbide by double impregnation and sol immobilisation. The obtained catalysts were characterised by N₂ adsorption at -196 ºC, high-resolution transmission electron...

Can disc diffusion susceptibility tests assess the antimicrobial activity of engineered nanoparticles?

The use of disc diffusion susceptibility tests to determine the antibacterial activity of engineered nanoparticles (ENPs) is questionable because their low diffusivity practically prevents them from penetrating through the culture media. In this study, we investigate the ability of such a test, namely the Kirby-Bauer disc diffusion test, to...

Hot Carrier Generation and Extraction of Plasmonic Alloy Nanoparticles

The conversion of light to electrical and chemical energy has the potential to provide meaningful advances to many aspects of daily life, including the production of energy, water purification, and optical sensing. Recently, plasmonic nanoparticles (PNPs) have been increasingly used in artificial photosynthesis (e.g., water splitting) devices...

All that glitters is gold: Nucleic acid detection using tethered gold

Tethered particle motion mediated by scattering from gold nanoparticles and darkfield microscopy

Gold nanoparticles: A novel application of spectral imaging in proteomics - preliminary results

The intense research in proteomics is demanding for fast, reliable and easy-to-use methods in order to study the proteome. In this proceeding we report the development of such a novel research tool based on spectral imaging and Resonance Light Scattering gold particles. This method will allow the study of DNA-protein interactions. We suggest a...