High Speed Electron Microscopy: Engineering of a commercial multi-beam scanning electron microscope with transmission imaging

In this thesis, the design and engineering considerations for a multi-beam scanning electron microscope (MBSEM) are discussed. This microscope can benefit biological research in various ways. It can give new insights into the inner workings of a multitude of biological systems that were hard to get using previously existing instrumentation. For...

Automated and high-throughput reactivity analysis in homogeneous catalysis: The deactivation complexity of Mn(I) hydrogenation catalysts

In this thesis, I highlighted a number of projects aimed at developing and testing new simulation methods for studying complex reactive systems, with a particular emphasis on simulation strategies based on the concept of bonding graphs. These mathematical structures provide useful tools for a variety of algorithms developed over the last few...

Ultra thin films for sensing and heating of microprobes

This dissertation aims to advance the current state of cantilevers with integrated metal thermal and deflection sensing elements. Metallic sensing elements enable the use of alternative substrate materials (such as polymers), that tend to exhibit higher compliance properties and are more robust (less brittle) compared to Si or Si3N4 cantilevers....

Vertical integration of high-throughput measurements to derive functional and regulatory interactions in S. cerevisiae

Bioinformatics concerns itself with developing data-driven tools for extracting biological information from high-throughput datasets (e.g. gene expression data, protein interaction data). Until recently, most of these tools focus on analyzing a single source of data. However, all high-throughput measurements are noisy and incomplete. Therefore,...

6-flow reactor: Catalyst testing in a multiphase-parallel packed-microreactor system

This thesis deals with the design and operation of a multiple-parallel powder-packed reactor with continuous gas and liquid flows for kinetic tests. The reactor design is discussed in detail. Subsequently, axial dispersion in a multiphase packed microreactor is treated. Also, it is described how to minimise segregation during the loading of a...

Chemometric Optimization Studies in Catalysis Employing High-Throughput Experimentation

The main topic of this thesis is the investigation of the synergies between High-Throughput Experimentation (HTE) and Chemometric Optimization methodologies in Catalysis research and of the use of such methodologies to maximize the advantages of using HTE methods. Several case studies were analysed including: 1) the exploration of a terpene...