Adjuvant holmium-166 radioembolization after radiofrequency ablation in early-stage hepatocellular carcinoma patients: a dose-finding study (HORA EST HCC trial)

Purpose: The aim of this study was to investigate the biodistribution of (super-)selective trans-arterial radioembolization (TARE) with holmium-166 microspheres (¹⁶⁶Ho-MS), when administered as adjuvant therapy after RFA of HCC 2–5 cm. The objective was to establish a treatment volume absorbed dose that results in an absorbed dose...

Polymeric micelles and the Dy-166/Ho-166 generator: A study of the loading mechanism of Dy/Dy-166 and Ho-166 into PCL-b-PEO polymeric micelles for imaging and cancer treatment

A radioisotope used in radionuclide therapy is Holmium-166 (Ho-166). The treatment effectiveness of Ho-166 could be improved by the use of a so called in vivo Dysprosium-166(Dy-166)/Ho-166 generator. The application of this generator is hindered by an effect called internal conversion (IC). This affect can arise after the decay of Dy-166 to Ho...

Increasing Specific Activity of ¹⁶⁶Ho through Szilard-Chalmers Effect in ¹⁶⁵Ho-loaded Zeolite A

Holmium-166 is a promising radionuclide for therapeutic and imaging applications due to its advantageous decay characteristics. However, these applications require or would benefit from a higher specific activity of ¹⁶⁶Ho than that obtained via a ¹⁶⁵Ho(n,γ)¹⁶⁶Ho reaction by irradiating a pure ¹⁶⁵Ho...

Iron oxide nanoparticles as carriers for the Dy-166/Ho-166 in vivo generator: A study into the characteristics and retention of Dy and Ho in iron oxide nanoparticles

Background:<br/>Cancer is one of the leading causes of death worldwide. Targeted radionuclide therapy has become a important treatment, this is when a carrier molecule is attached to a radionuclide to deliver cytotoxic radiation levels to diseased cells. β<br/>− emitters are frequently used in RNT because they have a long penetration depth, such...

Core–shell structured gold nanoparticles as carrier for ¹⁶⁶Dy/¹⁶⁶Ho in vivo generator

Background: Radionuclide therapy (RNT) has become a very important treatment modality for cancer nowadays. Comparing with other cancer treatment options, sufficient efficacy could be achieved in RNT with lower toxicity. β⁻ emitters are frequently used in RNT due to the long tissue penetration depth of the β⁻ particles....

Holmium-166 poly(L-lactic acid) microsphere radioembolisation of the liver: Technical aspects studied in a large animal mode