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Cussen, Kai (author)Thermo-responsive hydrogels are a class of smart material that show increasing promise and applications in the biomedical engineering industry. This thesis investigated a thermo-responsive hydrogel for 4D printing applications. A poly(N-isopropylacrylamide) (>97%) (pNIPAM) based hydrogel was developed and the concentration of NIPAM, as well...master thesis 2024
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Zhang, M. (author)Food and medicines are two of the most essential categories of goods for human beings, providing vital nourishment and healthcare. However, as these products are commercialized and distributed on a global scale, consumers face the threat of counterfeit and deteriorated products. In response, this dissertation presents four prototypes consisting...doctoral thesis 2024
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Liaudat, J. (author), Muraro, S. (author)Desiccation cracks in soils pose risks to the serviceability and safety of geotechnical infrastructure worldwide. This paper aims to investigate the potential of superabsorbent hydrogels (SAH) as innovative soil amendment to mitigate soil drying effects and cracking. Laboratory tests were conducted on an initially saturated silty soil treated...journal article 2024
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Zhang, M. (author), Raghunath, Aparna (author), Zhao, A. (author), Eral, H.B. (author)On-dose authentication (ODA) enhances security by incorporating customized molecular or micro-tags into each pill, preventing counterfeit products in genuine packages. ODA's security relies on tag non-replication and non-reverse engineering. Combining ODA with graphical Physical Unclonable Functions (PUF) promises maximum security. PUF uses...journal article 2024
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Zhou, Qiangqiang (author), Dai, Hanqing (author), Yan, Yukun (author), Qin, Zhiming (author), Zhou, Mengqi (author), Zhang, Wanlu (author), Zhang, Kouchi (author), Guo, Ruiqian (author), Wei, X. (author)The primary challenges posed by oral mucosal diseases are their high incidence and the difficulty in managing symptoms. Inspired by the ability of bioelectricity to activate cells, accelerate metabolism, and enhance immunity, a conductive polyacrylamide/sodium alginate crosslinked hydrogel composite containing reduced graphene oxide (PAA-SA...journal article 2024
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Beets, Josine (author)Incorporating living cells into a non-living matrix is one of the many possible steps that can be undertaken to stop climate change. Especially, photosynthetic organisms have a promising future in material design as they can capture atmospheric carbon dioxide and ’ breathe’ oxygen. This research dives into unravelling the properties of a...master thesis 2023
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- Kuo, Chihao (author) master thesis 2023
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Oh, J.J. (author), Ammu, S.K. (author), Vriend-Harwig, V.D. (author), Kieffer, R.Y. (author), Dr. Kleiner, F.K. (author), Balasubramanian, S. (author), Karana, E. (author), Masania, K. (author), Aubin-Tam, M.E. (author)Engineered living materials (ELMs) are a novel class of functional materials that typically feature spatial confinement of living components within an inert polymer matrix to recreate biological functions. Understanding the growth and spatial configuration of cellular populations within a matrix is crucial to predicting and improving their...journal article 2023
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Chen, Yuanyuan (author), Dai, Hanqing (author), Hu, Zhe (author), Wei, Jinxin (author), Zhou, Wenjie (author), Duan, Zhongtao (author), Cui, Zhongjie (author), Wei, Wei (author), Zhang, Kouchi (author)Hydrogel materials have biocompatibility, flexibility, transparency, self-healing ability, adhesion with various substrates, anti-freeze ability, and high-temperature resistance. However, the existing hydrogel devices cannot continue to operate in the case of damage, and they cannot work during the repair period, which brings great challenges...journal article 2023
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Jahanmard, F. (author), Khodaei, A. (author), Flapper, Jasper (author), Dogan, O. (author), Roohi, K. (author), Taheri, P. (author), Weinans, Harrie (author), Storm, G. (author), Croes, M. (author), Mastrobattista, E. (author), Amin Yavari, S. (author)Despite being the most widely used biomaterials in orthopedic surgery, metallic implants do not induce new bone growth because they are bioinert. Surface biofunctionalization of implants with immunomodulatory mediators is a recent approach to promote osteogenic factors that facilitate bone regeneration. Liposomes (Lip) can be used as a low-cost,...journal article 2023
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Wang, Hucheng (author), Fu, Xiaoming (author), Gu, Guanyao (author), Bai, Shengyu (author), Li, Runlai (author), Zhong, Weimin (author), Guo, Xuhong (author), Eelkema, R. (author), van Esch, J.H. (author), Cao, Zhixing (author), Wang, Yiming (author)Living organisms are capable of dynamically changing their structures for adaptive functions through sophisticated reaction-diffusion processes. Here we show how active supramolecular hydrogels with programmable lifetimes and macroscopic structures can be created by relying on a simple reaction-diffusion strategy. Two hydrogel precursors ...journal article 2023
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Schwab, Andrea (author), Wesdorp, Marinus A. (author), Xu, J. (author), Abinzano, Florencia (author), Loebel, Claudia (author), Levato, Riccardo (author), Eglin, David (author), Narcisi, Roberto (author), Malda, Jos (author), van Osch, G.J.V.M. (author)Background: The use of acellular hydrogels to repair osteochondral defects requires cells to first invade the biomaterial and then to deposit extracellular matrix for tissue regeneration. Due to the diverse physicochemical properties of engineered hydrogels, the specific properties that allow or even improve the behaviour of cells are not yet...journal article 2023
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Chen, Yuanyuan (author), Dai, Hanqing (author), Yan, Yukun (author), Piao, Zhiyan (author), Lu, Hanxu (author), Hu, Zhe (author), Wei, Wei (author), Zhang, Kouchi (author), Zhang, Wanlu (author), Guo, Ruiqian (author)In recent years, various functional fabrics capable of responding to multistimuli have been widely recognized as promising wearable devices. However, the obtained composite functional fabrics have only been applied in a few scenarios, rendering the achievement of multifunctional wearable application scenarios a difficult goal. Therefore,...journal article 2023
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Breve, T. (author)Smart materials are materials that are capable of responding in a programmable and predictive manner. Such materials respond to a broad variety of internal and external triggers and modulate one or more material properties accordingly. Common material responses are controlled release, color changes, morphological changes or changing the...doctoral thesis 2022
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Zhou, Liangbin (author), Guo, Peng (author), D'Este, Matteo (author), Tong, Wenxue (author), Xu, Jiankun (author), Yao, Hao (author), Stoddart, Martin J. (author), van Osch, G.J.V.M. (author), Ho, Kevin Ki Wai (author), Li, Zhen (author), Qin, Ling (author)Articular cartilage (AC) is an avascular and flexible connective tissue located on the bone surface in the diarthrodial joints. AC defects are common in the knees of young and physically active individuals. Because of the lack of suitable tissue-engineered artificial matrices, current therapies for AC defects, especially full-thickness AC...review 2022
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de Graaf, G. (author), Vriesendorp, Maurits Frans (author), Amin Hassan, H.M. (author), French, P.J. (author)In this research fluorescent optochemical pH probes for the detection of ischaemia have been investigated. Myocardial ischaemia is the most prominent risk during heart surgery. During open heart surgery the heart is temporarily arrested and, since there no blood flowing, oxygen supply and removal of waste products is stopped and heart cells...journal article 2022
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Neves Leal Costa, B. (author), Adão, Ricardo M.R. (author), Maibohm, Christian (author), Accardo, A. (author), Cardoso, Vanessa F. (author), Nieder, Jana B. (author)Biomimicking biological niches of healthy tissues or tumors can be achieved by means of artificial microenvironments, where structural and mechanical properties are crucial parameters to promote tissue formation and recreate natural conditions. In this work, three-dimensional (3D) scaffolds based on woodpile structures were fabricated by two...journal article 2022
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Zhang, M. (author), Warth, T. (author), Boon, N.J.H. (author), Demirörs, Ahmet Faik (author), Eral, H.B. (author)A microfluidic platform for continuous synthesis of hydrogel microparticles with superparamagnetic colloids (SPCs) embedded at prescribed positions is described. The shape of the cross-linked microparticle is independently controlled by stop–flow lithography, whereas the position of trapped SPCs are dictated by virtual magnetic moulds made of...journal article 2022
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Liu, Q. (author), Muralidharan, A. (author), Saateh, A. (author), Ding, Z. (author), ten Dijke, Peter (author), Boukany, P. (author)In the research of cancer cell invasion and metastasis, recreation of physiologically relevant and faithful three-dimensional (3D) tumor models that recapitulate spatial architecture, spatiotemporal control of cell communication and signaling pathways, and integration of extracellular cues remains an open challenge. Here, a programmable...journal article 2022
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Berkhout, Willemijn (author)Three-dimensional (3D) bioprinting studies the initial condition of printed constructs, which makes construct static, and neglects the dynamic changes in natural tissue conformation during tissue repair, disease progression and regeneration processes. Therefore, the concept of four-dimensional (4D) bioprinting has been introduced that allows for...master thesis 2021