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Tonin, F. (author), Marti, E. (author), Arends, I.W.C.E. (author), Hanefeld, U. (author)The specific oxidation of 12α-OH group of hydroxysteroids is required for the preparation of cheno-and ursodeoxycholic acid (CDCA and UDCA, respectively). The C<sub>12</sub> oxidation of hydroxysteroids into their 12-oxo derivatives can selectively be performed by employing 12α-hydroxysteroid dehydrogenases. These enzymes use NAD(P)<sup>+<...journal article 2020
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Tonin, F. (author), Alvarenga Da Silva, N. (author), Ye, Jia Zheng (author), Arends, I.W.C.E. (author), Hanefeld, U. (author)The C12 specific oxidation of hydroxysteroids is an essential reaction required for the preparation of pharmaceutical ingredients like ursodeoxycholic acid (UDCA) and chenodeoxycholic acid (CDCA), which can be synthesized by Wolff-Kishner reduction of the obtained 12-oxo-hydroxysteroids. 12α-hydroxysteroid dehydrogenases (12α-HSDHs) have...journal article 2019
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Tonin, F. (author), Arends, I.W.C.E. (author)Ursodeoxycholic acid (UDCA) is a pharmaceutical ingredient widely used in clinics. As bile acid it solubilizes cholesterol gallstones and improves the liver function in case of cholestatic diseases. UDCA can be obtained from cholic acid (CA), which is the most abundant and least expensive bile acid available. The now available chemical routes...review 2018