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Cosma, Bianca (author)<b>Motivation:</b> Imbalances in the human gut microbiome have been linked to various conditions, including inflammatory bowel disease (IBD), diabetes, and mental health disorders. While metagenomics and amplicon sequencing are the most commonly used technologies to characterize microbial communities, they do not capture all layers of functional...master thesis 2024
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Klomberg, Renz C.W. (author), van der Wal, Hella C. (author), Aardoom, Martine A. (author), Kemos, Polychronis (author), Rizopoulos, Dimitris (author), Ruemmele, Frank M. (author), Charrout, M. (author), Escher, Hankje C. (author), de Ridder, Lissy (author)Background and Aims<br/>Treatment guidelines for paediatric Crohn’s disease [CD] suggest early use of anti-tumour necrosis factor alpha [anti-TNFα] in high-risk individuals. The aim is to evaluate the effect of early anti-TNF in a real-world cohort.<br/><br/>Methods<br/>Children with newly diagnosed CD were prospectively recruited at 28...journal article 2024
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van Unen, Vincent (author), Ouboter, Laura F. (author), Li, Na (author), Schreurs, Mette (author), Abdelaal, T.R.M. (author), Kooy-Winkelaar, Yvonne (author), Beyrend, Guillaume (author), Höllt, T. (author), Maljaars, P. W.Jeroen (author), Mearin, M. Luisa (author), Mahfouz, A.M.E.T.A. (author), Witte, Anne M.C. (author), Clemens, Cornelis H.M. (author), Abraham, Sunje (author), Escher, Johanna C. (author), Lelieveldt, B.P.F. (author), Pascutti, M. Fernanda (author), van der Meulen – de Jong, Andrea E. (author), Koning, Frits (author)Chronic intestinal inflammation underlies inflammatory bowel disease (IBD). Previous studies indicated alterations in the cellular immune system; however, it has been challenging to interrogate the role of all immune cell subsets simultaneously. Therefore, we aimed to identify immune cell types associated with inflammation in IBD using high...journal article 2022
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Bourgonje, Arno R. (author), Hu, Shixian (author), Spekhorst, Lieke M. (author), Zhernakova, Daria V. (author), Vila, Arnau Vich (author), Li, Yanni (author), Charrout, M. (author), Mahfouz, A.M.E.T.A. (author), Reinders, M.J.T. (author)Background and Aims: Protein profiling in patients with inflammatory bowel diseases [IBD] for diagnostic and therapeutic purposes is underexplored. This study analysed the association between phenotype, genotype, and the plasma proteome in IBD. Methods: A total of 92 inflammation-related proteins were quantified in plasma of 1028 patients...journal article 2022
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Estévez-López, Fernando (author), Levelt, Lisa (author), van 't Veer, Job (author), Hrehovcsik, Micah M. (author), Visch, V.T. (author), Bramer, Wichor M. (author), Hillegers, Manon H.J. (author), van de Putte, Elise (author), Veltkamp, Remco C. (author)INTRODUCTION: Young people (aged 10-25 years) with chronic diseases are vulnerable to have reduced social participation and quality of life. It is important to empower young people to engage in their chronic diseases self-management. In comparison with traditional face-to-face care, interventions delivered through the internet and related...journal article 2022