Light Dosage Optimization by Data-driven and Dynamic Modeling: in Blue Light Therapies

The therapeutic properties of light have been known for thousands of years, but photodynamic therapy (PDT) was only developed in the last century. Currently, PDT is in clinical trials for the oncology-the treatment of head and neck, brain, lung, pancreas, abdominal cavity, breast, prostate, and skin cancer. Advantages of the light-based...

Analysis and data-based modeling of the photochemical reaction dynamics of the induced singlet oxygen in light therapies

Objective: The macroscopic singlet oxygen (MSO) model for quantifying the light-induced singlet oxygen ($^{1}O_{2}$) always contain a set of nonlinear dynamic equations and therefore are generally difficult to be applied. This work was devoted to analyze and simplify this dynamic model. Methods: Firstly, the nonlinearity of the MSO model was...