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Zwartveld, Stef (author)Subjective tinnitus is a sensation of sound without an external source. There is no clear understanding of the cause and pathology of tinnitus.<br/><br/>Literature suggests a combination of deafferentation of the tonotopic map , the Bayesian brain model, and the triple mode network, creating one combined hypothesis for tinnitus pathology. Based...master thesis 2024
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Wemelsfelder, Tom (author)In recent years, many therapeutic applications for medical ultrasound have arisen, such as ablation of tumors, breaking up kidney stones, and neuromodulation. To localize the target area, often ultrasound imaging methods are used. Conventionally, a different transducer array is used for imaging and therapeutic applications because of their...master thesis 2024
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Hueber, Paul (author)Designing processors for implantable closed-loop neuromodulation systems presents a formidable challenge owing to the constrained operational environment, which requires low latency and high energy efficacy. Previous benchmarks have provided limited insights into power consumption and latency. However, this study introduces algorithmic metrics...master thesis 2024
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Moisello, Elisabetta (author), Novaresi, Lara (author), Eshani Sarkar, E. (author), Malcovati, Piero (author), Lopes Marta da Costa, T.M. (author), Bonizzoni, Edoardo (author)Piezoelectric Micromachined Ultrasonic Transducers (PMUT) and Capacitive Micromachined Ultrasonic Transducers (CMUT) have seen great developments in recent years, both in terms of performance and scope of applications within the biomedical ultrasound domain. This paper presents a review of the state-of-the-art of PMUT and CMUT technologies,...review 2024
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Hueber, Paul (author), Tang, Guangzhi (author), Sifalakis, Manolis (author), Liaw, Hua Peng (author), Micheli, A. (author), Tömen, N. (author), Liu, Y. (author)Designing processors for implantable closed-loop neuromodulation systems presents a formidable challenge owing to the constrained operational environment, which requires low latency and high energy efficacy. Previous benchmarks have provided limited insights into power consumption and latency. However, this study introduces algorithmic...journal article 2024
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De Ridder, Dirk (author), Siddiqi, M.A. (author), Dauwels, J.H.G. (author), Serdijn, W.A. (author), Strydis, C. (author)Objectives: Current techniques in brain stimulation are still largely based on a phrenologic approach that a single brain target can treat a brain disorder. Nevertheless, meta-analyses of brain implants indicate an overall success rate of 50% improvement in 50% of patients, irrespective of the brain-related disorder. Thus, there is still a...review 2024
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Zhang, Yihao (author)Ultrasound (US) neuromodulation is a widely-used technique in the field of neuroscience and medical therapy that uses ultrasound waves to non-invasively modulate neural activity. The miniaturization of modern ultrasonic systems has an intimate relation with system power consumption. As the advancement of Integrated Circuits (ICs) represents a...master thesis 2023
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van Damme, Niels (author)In the emerging research field of bioelectronic medicine, it has been indicated that neuromodulation of the Vagus Nerve (VN) has the potential to treat various conditions such as epilepsy, depression, and autoimmune diseases. In order to reduce side effects, as well as to increase the effectiveness of the delivered therapy, sub-fascicle...master thesis 2023
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xue, chunyan (author)Vagus nerve stimulation serves as an approach to manage drug-resistant epilepsy. Focused ultrasound stands out as a unique tool, offering a non-invasive modality for VNS. With its excellent depth of penetration and sub-millimeter focusing capabilities in soft tissue, ultrasound allows for precise targeting of the vagus nerve without the need for...master thesis 2023
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Savundranayagam, Reka (author)In vitro neuromodulation studies play a crucial role in understanding the underlying interaction mechanisms between cells and ultrasound, which is important in the development of new therapies for various neurological disorders. Acoustic focusing, the ability to focus ultrasound at a specific focal length with high spatial resolution, provides a...master thesis 2023
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Varkevisser, F. (author), Lopes Marta da Costa, T.M. (author), Serdijn, W.A. (author)Developing neuroprosthetic bioelectronic devices requires wirelessly-powered implantable stimulator systems with hundreds to thousands of output channels. Power efficiency optimization is crucial for scaling up the number of output channels. Current-mode electrical stimulation is favored for safety but is power-inefficient in conventional...conference paper 2023
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Rivandi, H. (author), Lopes Marta da Costa, T.M. (author)Ultrasound (US) neuromodulation and ultrasonic power transfer to implanted devices demand novel ultrasound transmitters capable of steering focused ultrasound waves in 3D with high spatial resolution and US pressure, while having a miniaturized form factor. Meeting these requirements needs a 2D array of ultrasound transducers directly...journal article 2023
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Burghoorn, Niels (author)Medical technology has seen great progress over the last centuries, developing increasingly more specialised therapy to benefit human health. The rise of the pharmaceutical industry and the research it drives are contributors to this success. However, in humanity's attempt to tackle more and more complex health issues, the conventional methods...master thesis 2022
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Xiao, Yidi (author)Noninvasive brain stimulation plays an essential role in diagnosing and treating diseases of the brain. This stimulation can affect disease-related changes in brain activation, inhibition, or connectivity. Ultrasound neuromodulation is a rapidly growing field of noninvasive brain stimulation. In a form of acoustic pressure waves, ultrasound can...master thesis 2022
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Boerkamp, Christiaan (author)Neuromodulation of the vagus nerve is used as a treatment for all kinds of ailments and even as a means of improving the wearer's physiology, however, this form of treatment is not popular due to its invasive nature, high chance of side effects, and short period between reimplementation surgery, as such an alternative is sought in the form of...master thesis 2022
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Coolen, R.J.J. (author), Emmer, K.M. (author), Spantidea, P.I. (author), Asselt, E. van (author), Scheepe, J.R. (author), Serdijn, W.A. (author), Blok, B.F.M. (author)The first two objectives were to establish which stimulation parameters of kilohertz frequency alternating current (KHFAC) neuromodulation influence the effectiveness of pudendal nerve block and its safety. The third aim was to determine whether KHFAC neuromodulation of the pudendal nerve can relax the pelvic musculature, including the anal...journal article 2022
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Wardhana, G.K. (author), Mastrangeli, Massimo (author), Lopes Marta da Costa, T.M. (author)2D phased array ultrasonic transducers realized through the combination of bulk piezoelectric ceramics and complementary metal-oxide-semiconductor (CMOS) integrated circuits (IC) are enabling a new range of wearable ultrasound therapeutic applications. Traditional therapeutic ultrasound transducers have an air backing layer to maximize...conference paper 2022
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Rivandi, H. (author), Ghosh, Ishaan (author), Lopes Marta da Costa, T.M. (author)New non-imaging ultrasound applications, such as ultrasound stimulation and ultrasonic power transfer, need sub-millimeter volumetric spatial resolution, electronically control of the focal spot location, high ultrasound intensity, and a tiny form factor. Satisfying these requirements demands a high-frequency phased array ultrasound transducer....conference paper 2022
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Koele, Berend (author)Vagus nerve stimulation (VNS) has been proven to be an effective treatment for patients suffering from drug-resistant epilepsy. Current vagus nerve stimulators are either implantable devices or bulky, handheld devices. The implant consists of a pulse generator beneath the skin of the chest, connected to electrodes that are wired to the cervical...master thesis 2021
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Yang, Xinyu (author)The main objective of this thesis is to design a transmitter channel which is implemented in a 2D phased-array ultrasound neuromodulation system aiming for the vagus nerve stimulation. The vagus nerve has the widest distribution in the parasympathetic system and it oversees several important bodily functions such as the control of mood, immune...master thesis 2021
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