Searched for: subject%3A%22Optogenetics%22
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León González, Gonzalo (author)
Electronic interfaces, particularly microelectrode arrays (MEAs), are crucial for studying electrophysiological processes in the body, with applications ranging from implants to deep brain simulators. In neuroscience, they play a vital role in exploring neuronal cell distribution and behaviour, as well as disorders like epilepsy and Alzheimer’s...
master thesis 2024
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Quispe Haro, Juan José (author), Chen, Fei (author), Los, R. (author), Shi, Shuqi (author), Sun, Wenjun (author), Chen, Yong (author), Idema, T. (author), Wegner, Seraphine V. (author)
The transition of bacteria from an individualistic to a biofilm lifestyle profoundly alters their biology. During biofilm development, the bacterial cell-cell adhesions are a major determinant of initial microcolonies, which serve as kernels for the subsequent microscopic and mesoscopic structure of the biofilm, and determine the resulting...
journal article 2024
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Amini Hounejani, R. (author)
The past decades have seen the rapid development of many aspects of synthetic biology. For example, attempts to build synthetic cells under controlled conditions in the laboratory have led to significant achievements. Following a bottom-up approach, scientists aim at building a self-reproducing synthetic cell with a minimum number of biological...
doctoral thesis 2023
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Maddalena, L. (author), Pozzi, Paolo (author), Ceffa, Nicolò G. (author), Hoeven, Bas van der (author), Carroll, E.C.M. (author)
Light-sheet microscopy is a powerful method for imaging small translucent samples in vivo, owing to its unique combination of fast imaging speeds, large field of view, and low phototoxicity. This chapter briefly reviews state-of-the-art technology for variations of light-sheet microscopy. We review recent examples of optogenetics in...
book chapter 2023
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Laursen, Kjeld (author), Zamani, M. (author), Rezaeiyan, Y. (author), Hosseini, Seyedsina (author), Mondal, Tanmay (author), Corbett, Brian (author), Ouagazzal, Abdel Mouttalib (author), Amalric, Marianne (author), Moradi, Farshad (author)
This brief presents an ultrasonically powered micro-system for deep tissue optogenetic stimulation. The developed system is composed of a Base for Powering and Controlling (BPC) and an implantable Dust for optogenetics and drug delivery. The Dust consists of a piezoelectric crystal, a rectifier chip, and a micro-scale custom-designed light...
journal article 2023
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Nyns, Emile C.A. (author), Portero, Vincent (author), Deng, Shanliang (author), Jin, T. (author), Harlaar, Niels (author), Bart, Cindy I. (author), van Brakel, Thomas J. (author), Palmen, Meindert (author), Hjortnaes, Jesper (author), Ramkisoensing, Arti A. (author), Zhang, Kouchi (author), Poelma, René H. (author), Ördög, Balázs (author), de Vries, Antoine A.F. (author), Pijnappels, Daniël A. (author)
Background: Optogenetics could offer a solution to the current lack of an ambulatory method for the rapid automated cardioversion of atrial fibrillation (AF), but key translational aspects remain to be studied. Objective: To investigate whether optogenetic cardioversion of AF is effective in the aged heart and whether sufficient light...
journal article 2023
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Rashidi, A. (author), Zamani, M. (author), Mondal, Tanmay (author), Hosseini, Seyedsina (author), Laursen, Kjeld (author), Corbet, Brian (author), Moradi, Farshad (author)
This letter presents an ultrasonically powered dual-wavelength optogenetic device that targets simultaneous excitation and inhibition of neural activities, or in a broader sense, optical stimulation in two distinct wavelengths for targeting different populations of neurons. This can be applied to a variety of neurological disorders. The...
journal article 2023
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Portero, Vincent (author), Deng, Shanliang (author), Boink, Gerard J.J. (author), Zhang, Kouchi (author), de Vries, Antoine (author), Pijnappels, Daniël A. (author)
Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia, progressive in nature, and known to have a negative impact on mortality, morbidity, and quality of life. Patients requiring acute termination of AF to restore sinus rhythm are subjected to electrical cardioversion, which requires sedation and therefore hospitalization due to...
review 2023
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Ördög, Balázs (author), De Coster, Tim (author), Dekker, Sven O. (author), Bart, Cindy I. (author), Zhang, Juan (author), Boink, Gerard J.J. (author), Bax, Wilhelmina H. (author), Deng, Shanliang (author), den Ouden, B.L. (author), de Vries, Antoine A.F. (author), Pijnappels, Daniël A. (author)
To unlock new research possibilities by acquiring control of action potential (AP) morphologies in excitable cells, we developed an opto-electronic feedback loop-based system integrating cellular electrophysiology, real-time computing, and optogenetic approaches and applied it to monolayers of heart muscle cells. This allowed accurate...
journal article 2023
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Maddalena, L. (author)
Optogenetics is a powerful addition to the spectrum of techniques available in neuroscience to investigate neurophysiology and unravel how neural circuit structure is related to circuit function. This technique relies on introducing lightsensitive proteins or molecules as actuators to transduce an optical signal into a physiological perturbation...
doctoral thesis 2022
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Kostina, Polina (author)
The study of the electrophysiological properties of neurons has reached a new level thanks to recent techniques that combine knowledge from different fields of science. For a method such as all-optical electrophysiology, the quality of cell segmentation in the image has one of the critical roles since the accuracy of illumination and...
bachelor thesis 2022
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Faraj, Noura (author), Duinkerken, B. H.Peter (author), Carroll, E.C.M. (author), Giepmans, Ben N.G. (author)
Microscopic analysis of molecules and physiology in living cells and systems is a powerful tool in life sciences. While in vivo subcellular microscopic analysis of healthy and diseased human organs remains impossible, zebrafish larvae allow studying pathophysiology of many organs using in vivo microscopy. Here, we review the potential of the...
review 2022
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Nyns, Emile C.A. (author), Jin, T. (author), Bart, Cindy I. (author), Bax, Wilhelmina H. (author), Zhang, Kouchi (author), Poelma, René H. (author), de Vries, Antoine A.F. (author), Pijnappels, Daniël A. (author)
journal article 2022
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de Grip, Willem J. (author), Ganapathy, S. (author)
The first member and eponym of the rhodopsin family was identified in the 1930s as the visual pigment of the rod photoreceptor cell in the animal retina. It was found to be a membrane protein, owing its photosensitivity to the presence of a covalently bound chromophoric group. This group, derived from vitamin A, was appropriately dubbed retinal....
review 2022
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Nyns, Emile C.A. (author), Jin, T. (author), Fontes, Magda S. (author), van den Heuvel, Titus (author), Portero, Vincent (author), Bart, Cindy I. (author), Zeppenfeld, Katja (author), Zhang, Kouchi (author), Poelma, René H. (author)
AIMS: Ventricular tachyarrhythmias (VTs) are common in the pathologically remodelled heart. These arrhythmias can be lethal, necessitating acute treatment like electrical cardioversion to restore normal rhythm. Recently, it has been proposed that cardioversion may also be realized via optically controlled generation of bioelectricity by the...
journal article 2022
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Maddalena, L. (author), Ouwehand, M. (author), Safdar, H. (author), Carroll, E.C.M. (author)
In deep tissue imaging, pulsed near-infrared lasers commonly provide high peak powers needed for nonlinear absorption, but average power and linear absorption can be limiting factors for tissue damage through heat. We implemented intra-cavity dumping within a mode-locked Ti:Sapphire laser used for two-photon computer generated holography...
journal article 2022
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Bauer, Staf (author), van Wingerden, Nathalie (author), Jacobs, Thomas (author), van der Horst, Annabel (author), Zhai, Peipei (author), Betting, Jan Harm L.F. (author), Strydis, C. (author), White, Joshua J. (author), De Zeeuw, Chris I. (author), Romano, Vincenzo (author)
Neural activity exhibits oscillations, bursts, and resonance, enhancing responsiveness at preferential frequencies. For example, theta-frequency bursting and resonance in granule cells facilitate synaptic transmission and plasticity mechanisms at the input stage of the cerebellar cortex. However, whether theta-frequency bursting of Purkinje...
journal article 2022
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Krishnaswamy, Medha (author)
Optogenetics is a neuromodulation technique that uses light to control genetically modified cells to express light sensitive ion channels. Optogenetics allows stimulation of only the specific cells in the region that have been genetically modified and thus results in a high resolution of stimulation.<br/>Currently optogenetic implants are used...
master thesis 2021
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Velea, A. (author), Vollebregt, S. (author), Hosman, T.B. (author), Pak, A. (author), Giagka, Vasiliki (author)
This work aims to develop a smart neural interface with transparent electrodes to allow for electrical monitoring of the site of interest during optogenetic stimulation of the spinal cord. In this paper, a microfabrication process for the wafer-level development of such a compact, active, transparent and flexible implant is presented. Graphene...
conference paper 2020
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Velea, A. (author), Vollebregt, S. (author), Wardhana, G.K. (author), Giagka, Vasiliki (author)
This paper reports on the characterization of a microfabricated wafer-scale, graphene-based, soft implant for spinal cord applications. Graphene is used because of its high transparency and good conductivity, making it suitable for optogenetic applications. Moreover it has a high mechanical strength and is potentially biocompatible. The implant...
conference paper 2020
Searched for: subject%3A%22Optogenetics%22
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