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Rahmani, N. R. (author), Belluomo, R. (author), Kruyt, M. C. (author), Gawlitta, D. (author), Joosten, L. A.B. (author), Weinans, Harrie (author), Croes, M. (author)Macrophages are key regulators in bone repair and regeneration. Recent studies have shown that long-term epigenetic changes and metabolic shifts occur during specific immune training of macrophages that affect their functional state, resulting in heightened (trained) or reduced (tolerant) responses upon exposure to a second stimulus. This is...journal article 2024
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Vledder, Amária (author)Delayed healing or non-union of bone fractures are still clinically and economically relevant problems. Bone healing includes pro- and anti-inflammatory phases, which proved crucial for successful healing. Being able to modulate these inflammatory responses could potentially promote bone fracture healing. Dendritic cells play important roles in...master thesis 2022
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Khokhani, Paree (author), Rahmani, Nada R. (author), Kok, Anne (author), Öner, F. Cumhur (author), Alblas, Jacqueline (author), Weinans, Harrie (author), Kruyt, Moyo C. (author), Croes, Michiel (author)Therapeutic pathogen recognition receptor (PRR) ligands are reaching clinical practice following their ability to skew the immune response in a specific direction. We investigated the effects of various therapeutic PRR ligands on bone cell differentiation and inflammation. Following stimu-lation, alkaline phosphatase (ALP) activity (Day 10),...journal article 2021
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Croes, M. (author), Kruyt, M. C. (author), Boot, W. (author), Pouran, B. (author), Braham, M. V. (author), Pakpahan, S.A. (author), Weinans, Harrie (author), Vogely, H.C. (author), Fluit, A.C. (author), Dhert, W.J. (author), Alblas, J. (author), Öner, F.C. (author)Immune cells and their soluble factors regulate skeletal cells during normal bone regeneration and pathological bone formation. Bacterial infections can trigger immune responses that activate pro-osteogenic pathways, but these are usually overshadowed by osteolysis and concerns of systemic inflammation. The aim of this study was to determine...journal article 2019