Spatial lipidomics of coronary atherosclerotic plaque development in a familial hypercholesterolemia swine model

Coronary atherosclerosis is caused by plaque build-up, with lipids playing a pivotal role in its progression. However, lipid composition and distribution within coronary atherosclerosis remain unknown. This study aims to characterize lipids and investigate differences in lipid composition across disease stages to aid in the understanding of...

Development of a Patient-Specific Carotid Artery Fluid-Structure-Interaction Model

Background: <br/>Ischemic stroke is a major cause of death worldwide. Atherosclerosis in the carotid arteries is an established predictor of these events. FSI shows its advantage in simulating the hemodynamic environments due to involving the multiphysics coupling of fluid dynamics and structural mechanics regulations. Therefore, the aim of this...

From CTA to 3D modelling: A computational framework for morphometrical assessment and biomechanical analysis of atherosclerotic carotid arteries

Background: Ischemic stroke is a major cause of death worldwide. Atherosclerosis in the carotid arteries is an established predictor of these events. Ideally, patient-specific prevention plans can be developed that target advanced plaque development prior to events. Morphometry of advanced calcified plaque phenotypes can be assessed through...