Computational models for clinical drug response prediction: aligning transcriptomic data of patients and pre-clinical models

Extensive efforts in cancer research over the past decades have markedly improved diagnosis and treatments, leading to better outcomes for cancer patients. Paradoxically, however, these discoveries have begun to shed light on a level of complexity that rules out the emergence of a universal cancer treatment. As any tumor is now known to be...

Risk premium pricing methods in Non-Life Insurance for accurate estimation and uncertainty quantification

Free competition in the insurance markets increases the competitiveness and lowers the premiums. If insurers lower their premiums without having a model that accurately quantifies the expected claim size, they can be in serious trouble. This research aims to accurately model the premiums and quantify the uncertainty involved using historic...

Modeling and analyzing autogenous shrinkage of hardening cement paste

In this paper, a conceptual model for analyzing the plastic part of autogenous deformation of cement paste based on the Arrhenius rate theory will be presented. The autogenous deformation will be calculated from the elastic deformations with inclusion of creep. Different kinds of cement paste with a water cement ratio 0.3 are tested and studied,...