Data-driven product-process optimization of N-isopropylacrylamide microgel flow-synthesis

Microgels are cross-linked, colloidal polymer networks with great potential for stimuli-response release in drug-delivery applications, as their small size allows them to pass human cell boundaries. For applications with specified requirements regarding size, producing tailored microgels in a continuous flow reactor is advantageous because...

Domain-Knowledge-Driven Explainable Product Quality Prediction: Using prior knowledge to improve explanations of quality prediction models

Explainable artificial intelligence has in recent years allowed us to investigate how many machine learning methods are creating its predictions. This is especially useful in scenarios where the goal is not to predict a variable, but to explain what influences that variable. However, the methods that have been created thus far do not focus on...

A Self-Configurable and Self-Adjustable Digital Twin For a Production Process: A case study at FOCUS-ON

Digital Twins are a key component of Industry 4.0. They are a digital representation of a real-world entity containing both the structure and the dynamics of its real-world counterpart. The use of Digital Twins appears to offer a powerful an compelling application for production processes. A Self-configurable and self-adjustable Digital Twin is...

Scale up the process: The realization of industrial housing

Housing is a topic that concerns everyone, but the attention for housing has grown in the last years. There is an enormous urge for sufficient and affordable housing in a world where we cannot ignore globalisation. The market is looking for a way to answer this demand for affordable housing. Industrial housing is one of the answers. <br/><br/...

Reduction of cost, energy and emissions of the formalin production process via methane steam reforming

Production of formalin, which is among the highest production volume chemicals, is highly energy-intensive; thus, reduction of energy use is very important in reducing cost and emissions. The aim of this and its larger overall research is to systemically analyze how to improve sustainability of processes producing formalin as an intermediate...

Identifying and improving the internal and external information exchange for shipbuilding processes

To identify and improve the communication or information flow for a ship production process, this thesis provides an approach to use a Discrete Event Simulation (DES) model, based on Petri Net technique. By establishing a theoretical framework, the different simulation modelling options are analysed and based on practical requirements, a choice...

Adding human aspects to Planning Assistance Tools for complex logistical processes: a case-study of railway node planning in the Netherlands

Computers are preferred above humans when dealing with information processing because of the great memory and fast computing times. The use of algorithms within complex planning processes is an interesting research field. These algorithms should help human planners with the planning process and therefore are called Planning Assistance Tools (PAT...

Preparation of bio-bitumen by bio-oil based on free radical polymerization and production process optimization

Bio-oil produced during the production of biodiesel is a burden to the environment. Recycling and utilization of bio-oil as a substitute for pavement bitumen can help to build an environmentally-friendly and clean infrastructure. In this study, the bio-bitumen was prepared by bio-oil based on free radical polymerization. Different kinds of...

Latest development in the synthesis of ursodeoxycholic acid (UDCA): A critical review

Ursodeoxycholic acid (UDCA) is a pharmaceutical ingredient widely used in clinics. As bile acid it solubilizes cholesterol gallstones and improves the liver function in case of cholestatic diseases. UDCA can be obtained from cholic acid (CA), which is the most abundant and least expensive bile acid available. The now available chemical routes...

Analysis and Optimization of a Machined Steel Kit Manufacturing Process

IHC Metalix, a producer of machined steel kits for the shipbuilding industry, is currently in the process of improving production efficiency by modifying an existing crane as well as by installing two additional cranes, a pallet conveyor, and a pallet storage rack. The exact effects of these improvements on the production process have not been...

Achieving excellence in the aerospace industry: The development of a quality improvement method for innovative engineer-to-order processes at Fokker Services

Filament Winding. A Unified Approach

In this dissertation we have presented an overview and comprehensive treatment of several facets of the filament winding process. With the concepts of differential geometry and the theory of thin anisotropic shells of revolution, a parametric shape generator has been formulated for the design procedure of optimal composite pressure vessels in...

Electrostatic spray deposition of thin layers of cathode materials for lithium battery.