Real-Time Detection and Classification of Purkinje-Cell Neural Activity

Purkinje cell is a type of neuron that can be found in the cerebellum. What characterises Purkinje cell neural activity is the fact that it exhibits two types of spiking behaviour; the so-called simple and complex spikes. These two types of spikes are thought to play a role in motor functionality. In order to better understand the relationship...

Purkinje Cell Activity Resonation Generates Rhythmic Behaviors at the Preferred Frequency of 8 Hz

Neural activity exhibits oscillations, bursts, and resonance, enhancing responsiveness at preferential frequencies. For example, theta-frequency bursting and resonance in granule cells facilitate synaptic transmission and plasticity mechanisms at the input stage of the cerebellar cortex. However, whether theta-frequency bursting of Purkinje...

Balancing Long-term Plasticity Mechanisms at the Purkinje Cell in the Olivocerebellar System

The olivocerebellar system plays a crucial role in control of movements of the human body in terms of coordination, precision and timing. Long-term plasticity is directly linked to motor learning and control. In this research, we developed a phenomenological model of the olivocerebellar system with balancing of long-term potentiation (LTP) and...

WhiskEras: A New Algorithm for Accurate Whisker Tracking

Rodents engage in active touch using their facial whiskers: they explore their environment by making rapid back-and-forth movements. The fast nature of whisker movements, during which whiskers often cross each other, makes it notoriously difficult to track individual whiskers of the intact whisker field. We present here a novel algorithm,...

On correction prediction in man and robot using the cerebellar model articulation controller

The subject of this thesis is to investigate whether the Cerebellar Model Articulation Controller (CMAC) can be used to anticipate controller corrections and increase performance by reducing delays in humanoid robots. This question can be divided into two subquestions. Firstly, whether the CMAC is a suitable architecture for the prediction of...

Encoding of Correlated Temporal Information in a Model Cerebellar Loop with Olivary Oscillators and Long-Term Plasticity

The olivocerebellar system plays a central role in motor learning, crucially contributing to the coordination, precision and accurate timing of movements. The system is formed by Purkinje cells (PC), the Deep Cerebellar Nucleus (DCN) and Inferior Olive (IO). Its input activate the PC which produces simple (SS) and complex spikes (CS). The latter...

High frequency switched-mode stimulation can evoke post synaptic responses in cerebellar principal neurons

This paper investigates the efficacy of high frequency switched-mode neural stimulation. Instead of using a constant stimulation amplitude, the stimulus is switched on and off repeatedly with a high frequency (up to 100 kHz) duty cycled signal. By means of tissue modeling that includes the dynamic properties of both the tissue material as well...