Light Dosage Optimization by Data-driven and Dynamic Modeling: in Blue Light Therapies

The therapeutic properties of light have been known for thousands of years, but photodynamic therapy (PDT) was only developed in the last century. Currently, PDT is in clinical trials for the oncology-the treatment of head and neck, brain, lung, pancreas, abdominal cavity, breast, prostate, and skin cancer. Advantages of the light-based...

Enabling yeast replication in extreme cold and heat

Open questions are whether life can be enabled in uninhabitable environments, and whether there is a limit to howmuch one can tune the speed of proliferation. Answering such questions has broad implications. It may reveal whether we can live in unforeseen habitats, whether we can slow down aging, and whether there are limits to lifespan. In this...

Analysis and data-based modeling of the photochemical reaction dynamics of the induced singlet oxygen in light therapies

Objective: The macroscopic singlet oxygen (MSO) model for quantifying the light-induced singlet oxygen ($^{1}O_{2}$) always contain a set of nonlinear dynamic equations and therefore are generally difficult to be applied. This work was devoted to analyze and simplify this dynamic model. Methods: Firstly, the nonlinearity of the MSO model was...

Disinfection during Iron Electrocoagulation: Differentiating between Inactivation and Floc Entrapment for Escherichia coli and Somatic Coliphage Øx174

Electrochemical water treatment is gaining increasing popularity due to its wide range of potential applications, its decreasing costs, and its suitability as a decentralized treatment alternative, but mainly due to it being considered a "green technology". In the field of municipal wastewater treatment, the use of iron electrocoagulation (Fe...

Analyzing efficacy and safety of anti-fungal blue light therapy via kernel-based modeling the reactive oxygen species induced by light

Objective: The goal of this study is to investigate the efficacy, safety, and mechanism of ABL for inactivating Candida albicans (C. albicans), and to determine the best wavelength for treating candida infected disease, by experimental measurements and dynamic modeling. Methods: The changes in reactive oxygen species (ROS) in C. albicans and...

Inactivation of Escherichia coli and somatic coliphage ΦX174 by oxidation of electrochemically produced Fe²⁺

Electrochemical ferrous iron (Fe²⁺) wastewater treatment is gaining momentum for treating municipal wastewater due to its decreasing costs, environmental friendliness and capacity for removal of a wide range of contaminants. Disinfection by iron electrocoagulation (Fe-EC) has been occasionally reported in full scale industrial...

Physiological functions of the respiratory cytochrome bd and the CuA nitric oxide reductase (CuANor)

Biological membranes form a binding platform for a variety of proteins vital to the cell. The respiratory chain consists mostly of membrane-bound enzymes. These enzymes form a functional chain in which electrons derived from nutrition successively flow from low potential to high potential redox couples. During this process, the chemical energy...

Fenton Redox Chemistry: Arsenite Oxidation by Metallic Surfaces

Pre-oxidation of As(III) is necessary in arsenic removal processes in order to increase its efficiency. Therefore, the Fenton Redox Chemistry is defined by catalytic activation of H2O2 and currently common used for its redox oxidative properties. In this study the effect of H2O2 production catalysed by O2 in metallic surfaces (MS), such as...