Flow patterns in ascending aortic aneurysms: Determining the role of hypertension using phase contrast magnetic resonance and computational fluid dynamics

Thoracic aortic aneurysm (TAA) is a local dilation of the thoracic aorta. Although universally used, aneurysm diameter alone is a poor predictor of major complications such as rupture. There is a need for better biomarkers for risk assessment that also reflect the aberrant flow patterns found in TAAs. Furthermore, hypertension is often...

Data-driven generation of 4D velocity profiles in the aneurysmal ascending aorta

Background and Objective: Numerical simulations of blood flow are a valuable tool to investigate the pathophysiology of ascending thoratic aortic aneurysms (ATAA). To accurately reproduce in vivo hemodynamics, computational fluid dynamics (CFD) models must employ realistic inflow boundary conditions (BCs). However, the limited availability of...

Modelling and stabilization of coil deposition in intracranial aneurysm treatment: Improving the safety of neurovascular interventions

An intracranial aneurysm is a bulge in the cerebral vasculature. The rupture of an aneurysm results in a brain bleed. As a consequence, most patients become severely handicapped or may even die. Preventive treatment with endovascular coiling is controversial due to the high risk of complications. These complications are partly caused by the...

Hemodynamic Study of a Patient-Specific Intracranial Aneurysm: Comparative Assessment of Tomographic PIV, Stereoscopic PIV, In Vivo MRI and Computational Fluid Dynamics

Introduction: Wall shear stress (WSS) is associated with the growth and rupture of an intracranial aneurysm. To reveal their underlying connections, many image-based computational fluid dynamics (CFD) studies have been conducted. However, the methodological validations using both in vivo medical imaging and in vitro optical flow measurements...

Fabrication and Characterization of Self-Assembled Tissue Rings using Patient Cells with Variants in Aneurysm Genes

Aortic Abdominal Aneurysm (AAA) is a chronic degenerative disease of the arterial wall. The aortic vessel wall abnormally dilates due to multiple possible causes and may eventually rupture. It is characterized by several factors leading to the extreme dilation due to the degeneration of the vessel wall extracellular matrix (ECM). It is often...

Numerical investigation of turbulence in abdominal aortic aneurysms

Computational fluid dynamics (CFD) is a powerful method to investigate aneurysms. The primary focus of most investigations has been to compute various hemodynamic parameters to assess the risk posed by an aneurysm. Despite the occurrence of transitional flow in aneurysms, turbulence has not received much attention. In this article, we...

Numerical Analysis on Hemodynamics in Intracranial Aneurysms: Proposing a third hemodynamic criterion for predicting rupture sites

Brain aneurysms cause almost 500,000 deaths in the world every year. A better understanding of brain aneurysm genesis and rupture may open new opportunities to prevention and treatment. In this study, a part of the cerebral vascular system, the so called circle of Willis including an aneurysm, was analyzed with Computational Fluid Dynamics (CFD)...

Turbulence in Aneurysms: Numerical Investigation in Abdominal Aortic Aneurysms

An aneurysm refers to the local dilation or ballooning of a blood vessel and if left unchecked, almost every aneurysm continues to grow in size until it eventually ruptures. The abdominal aorta is the most common location for an aneurysm to form and an abdominal aortic aneurysm (AAA) can turn lethal in the event of rupture. Since the current...

CFD Modeling of Abdominal Aortic Aneurysms

An abdominal aortic aneurysm (AAA) is an excessive localized swelling of the abdominal aortic wall. AAAs are often lethal when they rupture and constitute a significant health risk in the developed countries. CFD simulations can help predict formation, progression, and rupture of AAAs by the use of hemodynamic parameters such as the Oscillatory...

Intracranial aneurysm segmentation in 3D CT angiography: Method and quantitative validation

Comparison of PC-MRI and PIV measurements in an aneurysm phantom

Blood flow and the associated shear forces have important biological effects on blood vessels. It has been suggested that blood flow abnormalities play a part in the development and the rupture of a deformed part of the wall of a brain artery, which is called an intracranial aneurysm, and thus in cerebral hemorrhages. Knowledge about the blood...

The influence of asymmetric inflow in abdominal aortic aneurysm hemodynamics

Inflow asymmetry has been found to strongly influence the hemodynamics in arterial geometries. Flow asymmetry is commonly found within the aortic conduit just proximal of the aneurysmal expansion and is caused by the remodeling of the abdominal aorta required to accommodate the excess volume of the distended vessel. In an effort to improve the...

Numerical analysis of aneurysm using pulsatile blood flow through a locally expanded vessel

A numerical analysis based on a finite volume approach is employed for a 2-D axisymmetric, incompressible, laminar and transient flow in order to simulate the pulsatile blood flow in aneurysm. The unsteady nature of the blood is studied for three Womersley numbers and for three rheological models including Newtonian, Power law and Quemada. A...

Simulation of aneurysm in different sections of aorta artery

By using CFD method, Fluent code , Aneurysm of specific locations of aorta artery have been simulated .For ascending, descending and abdominal aorta, aneurysm of different sizes and diameters are modeled. Geometrical data of aorta's sections have been extracted from physiological texts. Locations of hypothetical aneurysms are placed in the...

The influence of assymetric inflow in abdominal aortic aneurysm hemodynamics

Inflow asymmetry has been found to strongly influence the hemodynamics in arterial geometries. Flow asymmetry is commonly found within the aortic conduit just proximal of the aneurysmal expansion and is caused by the remodeling of the abdominal aorta required to accommodate the excess volume of the distended vessel. In an effort to improve the...

Silicone arteries: High-tech Polyfilla repairs life-threatening aneurysms