Trick and treat: Cell-instructive and bactericidal nanopatterns for bone implants

Bacterial adherence on 3-D printed plasma electrolytic oxidized titanium implants in dynamic conditions

Osteoarthritis, the degeneration of articular cartilage, which causes loss of mobility and chronic pain for patients is a common condition with high clinical demand. Care of this condition currently attributes to ±1.4% of the Dutch annual health care costs, but due to the rapidly aging Dutch population a 41% increase of cases is projected over...

Influence of interspace and controlled disorder on bactericidal properties of nanopatterns

Patients with orthopaedic implants often experience implant-associated infections (IAI), one of the most prominent causes for implant failure. IAIs are caused by pathogens adhering to the implant surface. One method to prevent IAIs is through the use of surface topography modifications. Cellular behaviour has been shown to be influenced by...

Towards osteogenic and bactericidal nanopatterns?

Recent discoveries have shown that nanopatterns with feature sizes ≤100 nm could direct stem cell fate or kill bacteria. These effects could be used to develop orthopedic implants with improved osseointegration and decreased chance of implant-associated infections. The quest for osteogenic and bactericidal nanopatterns is ongoing but no...

Effective bactericidal nanopillars for E. coli and S. aureus

Due to competition of host and bacterial cells to adhere and grow on implant surfaces, implants are frequently associated with a high risk of peri-implant infections. The microorganisms that are abundantly present during peri-implant infections are Staphylococcus bacteria and a variety of other less abundant bacteria as for example Escherichia...

A finite element model to determine the bactericidal and cytotoxic properties of nanopatterned surfaces: A parametric study

The fundamentals of the nanopatterned surface can be found on the wings of cicada. These bactericidal surfaces are artificially mimicked on the surface of the implant to reduce the infection rate, which is one of the main complication after joint replacement. The bactericidal properties of the nanopatterned surface are a promising feature....

Bacterial Cells Response to Osteogenic Nanopatterns

The presence of implants in the body is frequently associated with a high risk of peri-implant infections. The host and the bacterial cells compete to adhere and grow on the implant surface. Therefore, producing an implant that can promote the stem cells function (e.g., osteogenic differentiation) while reducing bacterial colonization is vital....